N-(2-methylbenzoyl)-2-nitroanilide

Base Information

• Chemical Name: N-(2-methylbenzoyl)-2-nitroanilide
• CAS No.: 50850-13-0
• Molecular Formula: C₁₄H₁₂N₂O₃
• Molecular Weight: 256.261
• Mol file: 50850-13-0.mol

Synonyms:N-(2-methylbenzoyl)-2-nitroanilide

Chemical Property of N-(2-methylbenzoyl)-2-nitroanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-methylbenzoyl)-2-nitroanilide

There total 6 articles about N-(2-methylbenzoyl)-2-nitroanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trimethylsilyl 2-methylbenzoate (55557-15-8) + 2-nitro-aniline (88-74-4) → N-(2-methylbenzoyl)-2-nitroanilide (50850-13-0)

Guidance literature:

With 4-(trifluoromethyl)benzoic anhydride; silver trifluoromethanesulfonate; titanium tetrachloride; In dichloromethane; for 20h; Ambient temperature;

DOI:10.1246/cl.1993.1053

Reference yield: 92.0%

ortho-toluoyl chloride (933-88-0) + 2-nitro-aniline (88-74-4) → N-(2-methylbenzoyl)-2-nitroanilide (50850-13-0)

Guidance literature:

With pyridine; In tetrahydrofuran; for 5h; Ambient temperature;

DOI:10.1021/jm970096g

Reference yield: 80.0%

2-nitro-aniline (88-74-4) + 2-methylbenzoic anhydride (607-86-3) → N-(2-methylbenzoyl)-2-nitroanilide (50850-13-0)

Guidance literature:

With tin(II) trifluoromethanesulfonate; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1246/bcsj.67.210

upstream raw materials:

ortho-toluoyl chloride

2-nitro-aniline

trimethylsilyl 2-methylbenzoate

2-methylbenzoic anhydride

Downstream raw materials:

2-iodo-6-methyl-2'-nitrobenzanilide

2-(2-methylphenyl)benzimidazole

2'-Amino-2-methylbenzanilid

Refernces

• 1、 -. "Substituted benzimidazoles, and methods of use thereof, for the inhibition of HIV reverse transcription and for the treatment of HIV infection". Example 8. . Retrieved 2008/06/13.
• 2、 Miyashita, Mitsutomo,Shiina, Isamu,Mukaiyama, Teruaki. "An Effective Method for Acylation of Weakly Nucleophilic Anilines with Silyl Carboxylates via Mixed Anhydrides". . p. 210 - 215. Retrieved 2007/10/02.