METHYL 4-BROMO-3-FLUOROBENZOATE 98

Base Information

• Chemical Name: METHYL 4-BROMO-3-FLUOROBENZOATE 98
• CAS No.: 849758-12-9
• Molecular Formula: C8H6BrFO2
• Molecular Weight: 233.037
• Hs Code.: 2916399090
• Mol file: 849758-12-9.mol

Synonyms:4-Bromo-3-fluorobenzoicacid methyl ester;Methyl 4-bromo-3-fluorobenzoate;

Chemical Property of METHYL 4-BROMO-3-FLUOROBENZOATE 98

Chemical Property:

• Vapor Pressure: 0.007mmHg at 25°C
• Melting Point: 64-66 °C
• Refractive Index: 1.531
• Boiling Point: 270.079 °C at 760 mmHg
• Flash Point: 117.14 °C
• PSA: 26.30000
• Density: 1.578 g/cm³
• LogP: 2.37480
• Storage Temp.: Keep Cold
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 4-Bromo-3-fluorobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-BROMO-3-FLUOROBENZOATE 98

There total 4 articles about METHYL 4-BROMO-3-FLUOROBENZOATE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 4-bromo-3-fluorobenzoic acid (153556-42-4) → methyl 4-bromo-3-fluorobenzoate (849758-12-9)

Guidance literature:

With thionyl chloride; at 80 ℃; for 5h;

Reference yield: 100.0%

4-bromo-3-fluorobenzoic acid (153556-42-4) + methyl iodide (74-88-4) → methyl 4-bromo-3-fluorobenzoate (849758-12-9)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

Reference yield: 99.0%

→ methyl 4-bromo-3-fluorobenzoate (849758-12-9)

Guidance literature:

With sodium ethanolate; In ethanol; at 0 - 20 ℃; for 4h;

upstream raw materials:

4-bromo-3-fluorobenzoic acid

diazomethyl-trimethyl-silane

methanol

methyl iodide

Downstream raw materials:

methyl 4-[(1E)-3-tert-butoxy-3-oxoprop-1-en-1-yl]-3-fluorobenzoate

4-bromo-3-fluorobenzohydrazide

4-(4-methyl-piperazin-1-yl)-3-fluoro-benzoic acid methyl ester

Refernces

• 1、 Skepper, Colin K.,Armstrong, Duncan,Balibar, Carl J.,Bauer, Daniel,Bellamacina, Cornelia,Benton, Bret M.,Bussiere, Dirksen,De Pascale, Gianfranco,De Vicente, Javier,Dean, Charles R.,Dhumale, Bhavesh,Fisher, L. Mark,Fuller, John,Fulsunder, Mangesh,Holder, Lauren M.,Hu, Cheng,Kantariya, Bhavin,Lapointe, Guillaume,Leeds, Jennifer A.,Li, Xiaolin,Lu, Peichao,Lvov, Anatoli,Ma, Sylvia,Madhavan, Shravanthi,Malekar, Swapnil,McKenney, David,Mergo, Wosenu,Metzger, Louis,Moser, Heinz E.,Mutnick, Daniel,Noeske, Jonas,Osborne, Colin,Patel, Ashish,Patel, Darshit,Patel, Tushar,Prajapati, Krunal,Prosen, Katherine R.,Reck, Folkert,Richie, Daryl L.,Rico, Alice,Sanderson, Mark R.,Satasia, Shailesh,Sawyer, William S.,Selvarajah, Jogitha,Shah, Nirav,Shanghavi, Kartik,Shu, Wei,Thompson, Katherine V.,Traebert, Martin,Vala, Anand,Vala, Lakhan,Veselkov, Dennis A.,Vo, Jason,Wang, Michael,Widya, Marcella,Williams, Sarah L.,Xu, Yongjin,Yue, Qin,Zang, Richard,Zhou, Bo,Rivkin, Alexey. "Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria". . p. 7773 - 7816. Retrieved 2020/07/21.
• 2、 -. "CANCER TREATMENTS TARGETING CANCER STEM CELLS". Paragraph 0331; 0643-0645. . Retrieved 2019/11/19.