2-Amino-5-chloromethylpyrimidine

Base Information

• Chemical Name: 2-Amino-5-chloromethylpyrimidine
• CAS No.: 120747-86-6
• Molecular Formula: C₅H₆ClN₃*ClH
• Molecular Weight: 180.037
• Hs Code.: 2933599590
• Mol file: 120747-86-6.mol

Synonyms:2-Pyrimidinamine,5-(chloromethyl)-, monohydrochloride (9CI);2-Amino-5-chloromethylpyrimidine hydrochloride;

Chemical Property of 2-Amino-5-chloromethylpyrimidine

Chemical Property:

• Vapor Pressure: 4.78E-05mmHg at 25°C
• Refractive Index: 1.604
• Boiling Point: 349.2ºC at 760mmHg
• Flash Point: 165ºC
• PSA: 51.80000
• Density: 1.356g/cm3
• LogP: 2.18080

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-(chloromethyl)pyrimidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-chloromethylpyrimidine

There total 1 articles about 2-Amino-5-chloromethylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(2-aminopyrimidin-5-yl)methanol (120747-85-5) → C5H6ClN3*ClH (120747-86-6)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 20 ℃;

Reference yield: 83.0%

C5H6ClN3*ClH (120747-86-6) → 5-(aminomethyl)pyrimidin-2-amine (672324-80-0)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 48h;

upstream raw materials:

(2-aminopyrimidin-5-yl)methanol

Downstream raw materials:

5-(aminomethyl)pyrimidin-2-amine

Refernces

• 1、 -. "Pyrazolotriazines as kinase inhibitors". Page/Page column 17. . Retrieved 2008/06/13.