N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide

Base Information Edit

Chemical Name:N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide
CAS No.:848133-76-6
Molecular Formula:C14H12ClN3O2
Molecular Weight:289.721
Hs Code.:2933499090
European Community (EC) Number:619-565-5
UNII:U9EM282PCG
DSSTox Substance ID:DTXSID20463512
Nikkaji Number:J3.273.597E
Wikidata:Q72517951
Mol file:848133-76-6.mol

Synonyms:848133-76-6;N-(4-CHLORO-3-CYANO-7-ETHOXY-6-QUINOLINYL)ACETAMIDE;N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide;N-(4-CHLORO-3-CYANO-7-ETHOXY-6-QUINOLINYL) ACETAMIDE;Acetamide, N-(4-chloro-3-cyano-7-ethoxy-6-quinolinyl)-;U9EM282PCG;MFCD09263704;C14H12ClN3O2;UNII-U9EM282PCG;EC 619-565-5;4-Chloro-3-cyano-7-ethoxy-6-(N-acetylamino)quinoline;6-Acetamido-4-chloro-7-ethoxyquinoline-3-carbonitrile;SCHEMBL2129771;DTXSID20463512;XDXGFTCQRAQEEG-UHFFFAOYSA-N;AMY13639;BCP10620;AKOS015843794;AB50210;GS-0943;AC-29708;SY047092;C3315;CS-0001077;FT-0601772;NS00005433;4-chloro-3-cyano-7-ethoxy-6N-acetylquinoline;4-chloro-3-cyano-7-ethoxy-6-N-acetylquinoline;A840939;4-chloro-3-cyano-7-ethoxy-6-acetylamino quinoline;N-(4-chloro-3-cyano-7-ethoxy-quinolin-6-yl)-acetamide;4-CHLORO-3-CYANO-7-ETHOXY-6-(ACETYLAMINO)QUINOLINE;N-(4-chloranyl-3-cyano-7-ethoxy-quinolin-6-yl)ethanamide

Suppliers and Price of N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide
1g
$ 70.00

TCI Chemical
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide >98.0%(HPLC)(N)
1g
$ 63.00

TCI Chemical
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide >98.0%(HPLC)(N)
5g
$ 187.00

SynChem
N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide 95+%
250 mg
$ 250.00

SynChem
N-(4-Chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide 95+%
1 g
$ 895.00

Sigma-Aldrich
N-(4-chloro-3-cyano-7-ethoxyquinolin-6-yl)acetamide
1g
$ 775.00

Matrix Scientific
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 95%
5g
$ 132.00

Matrix Scientific
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 95%
1g
$ 43.00

Matrix Scientific
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl) acetamide 95%
25g
$ 438.00

Labseeker
N-(4-CHLORO-3-CYANO-7-ETHOXY-6-QUINOLINYL)ACETAMIDE 98
100g
$ 533.00

Total 122 raw suppliers

Chemical Property of N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide Edit

Chemical Property:

Vapor Pressure:7.35E-11mmHg at 25°C
Melting Point:250°C(lit.)
Refractive Index:1.624
Boiling Point:518.6 °C at 760 mmHg
PKA:13.13±0.43(Predicted)
Flash Point:267.5 °C
PSA：75.01000
Density:1.35 g/cm³
LogP:3.18998
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:DMSO (Slightly, Heated)
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:289.0618043
Heavy Atom Count:20
Complexity:409

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(C=C2C(=C1)N=CC(=C2Cl)C#N)NC(=O)C
Uses N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide is used in synthesis of an antitumor agent, neratinib (N390090).

Technology Process of N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide

There total 44 articles about N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

: C₁₂H₈ClN₃O₆

: 108-24-7
acetic anhydride

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

Guidance literature:: C₁₂H₈ClN₃O₆; With ammonium iodide; 5%-palladium/activated carbon; hydrogen; In methanol; at 30 - 35 ℃; for 6h; under 1500.15 - 2250.23 Torr; Autoclave;

acetic anhydride; In tetrahydrofuran; at 50 - 55 ℃; for 5h; Pressure; Temperature; Reagent/catalyst; Solvent;

Reference yield: 93.6%

: 848133-75-5
3-cyano-4-hydroxyl-6-acetamido-7-ethoxyquinoline

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

Guidance literature:: With trichlorophosphate; In diethylene glycol dimethyl ether; at 85 ℃; for 4 - 4.5h; Product distribution / selectivity;