5-Thiazolamine

Base Information

• Chemical Name: 5-Thiazolamine
• CAS No.: 17721-00-5
• Molecular Formula: C3H4N2S
• Molecular Weight: 100.144
• Hs Code.: 2934100090
• European Community (EC) Number: 640-655-5
• DSSTox Substance ID: DTXSID30497267
• Nikkaji Number: J82.667G
• Wikidata: Q72508215
• Mol file: 17721-00-5.mol

Synonyms:5-aminothiazole

Chemical Property of 5-Thiazolamine

Chemical Property:

• Boiling Point: 239.313 °C at 760 mmHg
• PKA: 4.01±0.10(Predicted)
• Flash Point: 98.533 °C
• PSA: 67.15000
• Density: 1.345 g/cm³
• LogP: 1.30650
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 100.00951931
• Heavy Atom Count: 6
• Complexity: 48.1

Purity/Quality:

99% ^*data from raw suppliers

5-Aminothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(SC=N1)N

Technology Process of 5-Thiazolamine

There total 4 articles about 5-Thiazolamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiazole-5-carboxylic acid (14527-41-4) → 1,3-thiazol-5-amine (17721-00-5)

Guidance literature:

thiazole-5-carboxylic acid; With diphenyl phosphoryl azide; In tert-Amyl alcohol; triethylamine; for 8h; Heating;

With hydrogenchloride; In 1,4-dioxane; methanol; at 0 ℃;

DOI:10.1016/j.bmcl.2008.07.093

Reference yield:

N-thiazol-5-yl-phthalimide (99972-05-1) → 1,3-thiazol-5-amine (17721-00-5)

Guidance literature:

With ethanol; hydrazine hydrate;

DOI:10.1002/hlca.19480310225

Reference yield:

N-formylamino-acetonitrile (5018-27-9) → 1,3-thiazol-5-amine (17721-00-5)

Guidance literature:

With pyridine; hydrogen sulfide; trichlorophosphate; Yield given. Multistep reaction;

DOI:10.1139/v86-185

upstream raw materials:

N-thiazol-5-yl-phthalimide

N-formylamino-acetonitrile

thiazole-5-carboxylic acid

Downstream raw materials:

C₁₈H₁₈N₄S

N-acetyl-4-[bis-(2-chloro-ethyl)-amino]-phenylalanine thiazol-5-ylamide

N-(thiazol-5-yl)acetamide

methyl (2Z)-4-{(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-methoxy-3,3,11-trimethyl-11-(4-methylpent-3-en-1-yl)-13-[(2E)-3-methyl-4-(thiazol-5-ylamino)but-2-en-1-yl]-7,15-dioxo-3H,11H-1,5-methanofuro[3,4-g]pyrano[3,2-b]xanthen-1-yl}-2-methylbut-2-enoate

Refernces

• 1、 Scott, David A.,Aquila, Brian M.,Bebernitz, Geraldine A.,Cook, Donald J.,Dakin, Les A.,Deegan, Tracy L.,Hattersley, Maureen M.,Ioannidis, Stephanos,Lyne, Paul D.,Omer, Charles A.,Ye, Minwei,Zheng, XiaoLan. "Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer". scheme or table. p. 4794 - 4797. Retrieved 2009/05/30.