2-Amino-4-methoxyphenol

Base Information

• Chemical Name: 2-Amino-4-methoxyphenol
• CAS No.: 20734-76-3
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2922509090
• European Community (EC) Number: 687-284-5
• DSSTox Substance ID: DTXSID40362896
• Nikkaji Number: J83.009G
• Wikidata: Q72438805
• ChEMBL ID: CHEMBL1622271
• Mol file: 20734-76-3.mol

Synonyms:2-amino-4-methoxyphenol;20734-76-3;2-Amino-4-methoxy-phenol;Phenol, 2-amino-4-methoxy-;4-methoxy-2-aminophenol;MFCD06616911;Asinex-Reag Bas 13015559;2-Hydroxy-5-methoxyaniline;2-azanyl-4-methoxy-phenol;2-amino-4-(methyloxy)phenol;SCHEMBL245052;CHEMBL1622271;2-Amino-4-methoxyphenol, 95%;BDBM50488;cid_3015618;DTXSID40362896;BBL000043;GEO-03978;STK507062;AKOS000108842;2-amino-4-methoxy-phenol;hydrochloride;AB25358;CS-W001213;HY-W001213;PS-3110;NCGC00245441-01;AM808200;SY035371;BB 0245394;FT-0659324;EN300-85215;A814846;W-206550;Z57727878

Chemical Property of 2-Amino-4-methoxyphenol

Chemical Property:

• Vapor Pressure: 0.00129mmHg at 25°C
• Melting Point: 135-137℃
• Refractive Index: 1.599
• Boiling Point: 289.1 °C at 760 mmHg
• PKA: 10.24±0.18(Predicted)
• Flash Point: 128.7 °C
• PSA: 55.48000
• Density: 1.157 g/cm³
• LogP: 1.56420
• Storage Temp.: 2-8°C
• Sensitive.: Air Sensitive
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-4-methoxyphenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi
• Hazard Codes: T,Xi,Xn
• Statements: 22-52/53
• Safety Statements: 61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)O)N

Technology Process of 2-Amino-4-methoxyphenol

There total 10 articles about 2-Amino-4-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-2-nitrophenol (1568-70-3) → 2-amino-4-methoxyphenol (20734-76-3)

Guidance literature:

With palladium on activated carbon; hydrogen; In methanol; water; for 40h;

DOI:10.1002/chem.201701758

Reference yield: 64.0%

→ 2-amino-4-methoxyphenol (20734-76-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; under 760.051 Torr; Inert atmosphere;

Reference yield: 50.0%

4-methoxy-2-nitrophenol (1568-70-3) + N,N-diethylaniline (91-66-7) → 5-Methoxy-2-methyl-benzoxazole (5676-57-3) + 2-amino-4-methoxyphenol (20734-76-3)

Guidance literature:

at 210 - 215 ℃; for 1.5h;

DOI:10.3987/COM-04-S(P)11

upstream raw materials:

4-methoxy-2-nitrophenol

2,5-dimethoxyaniline

4-Methoxy-2-phenylazo-phenol

4-(2-Hydroxy-5-methoxy-phenylazo)-benzenesulfonamide

Downstream raw materials:

5-methoxy-3H-benzooxazol-2-one

N-(2-hydroxy-5-methoxyphenyl)acetamide

2-acetamido-4-methoxyphenylacetate

2-amino-5-methoxybenzoxazole

Refernces

• 1、 -. "METHODS AND COMPOSITIONS FOR MODULATING SPLICING". Paragraph 0620; 0654; 0754. . Retrieved 2020/08/22.
• 2、 Le, Thuy G.,Kundu, Abhijit,Ghoshal, Atanu,Nguyen, Nghi H.,Preston, Sarah,Jiao, Yaqing,Ruan, Banfeng,Xue, Lian,Huang, Fei,Keiser, Jennifer,Hofmann, Andreas,Chang, Bill C. H.,Garcia-Bustos, Jose,Wells, Timothy N. C.,Palmer, Michael J.,Jabbar, Abdul,Gasser, Robin B.,Baell, Jonathan B.. "Structure-Activity Relationship Studies of Tolfenpyrad Reveal Subnanomolar Inhibitors of Haemonchus contortus Development". . p. 1036 - 1053. Retrieved 2019/01/14.