N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate

Base Information

• Chemical Name: N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate
• CAS No.: 1076242-70-0
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₆FN₃O₅
• Molecular Weight: 545.488
• Mol file: 1076242-70-0.mol

Synonyms:N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate

Chemical Property of N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate

There total 2 articles about N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-methoxyphenyl]acetamide trifluoroacetate (1076242-68-6) → N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate (1076242-70-0)

Guidance literature:

With boron tribromide; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

4-(4-fluorobenzyl)-1-[(2S)-oxiran-2-ylmethyl]piperazin-2-one (1076242-98-2) + N-(2-hydroxy-4-methoxyphenyl)acetamide (58469-06-0) → N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-hydroxyphenyl]acetamide trifluoroacetate (1076242-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

2: boron tribromide / dichloromethane / 4 h / 20 °C

With boron tribromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

N-[2-({(2S)-3-[4-(4-fluorobenzyl)-2-oxo-piperazin-1-yl]-2-hydroxypropyl}oxy)-4-methoxyphenyl]acetamide trifluoroacetate

4-(4-fluorobenzyl)-1-[(2S)-oxiran-2-ylmethyl]piperazin-2-one

N-(2-hydroxy-4-methoxyphenyl)acetamide

Refernces