3-(3-Chlorophenyl)-N-methylpropan-1-amine

Base Information

• Chemical Name: 3-(3-Chlorophenyl)-N-methylpropan-1-amine
• CAS No.: 103275-33-8
• Molecular Formula: C₁₀H₁₄ClN
• Molecular Weight: 183.681
• DSSTox Substance ID: DTXSID301292635
• Mol file: 103275-33-8.mol

Synonyms:103275-33-8;3-(3-CHLOROPHENYL)-N-METHYLPROPAN-1-AMINE;[3-(3-CHLORO-PHENYL)-PROPYL]-METHYL-AMINE;BENZENEPROPANAMINE, 3-CHLORO-N-METHYL-;SCHEMBL9326799;DTXSID301292635;3-Chloro-N-methylbenzenepropanamine;N-Methyl-3-chlorobenzenepropanamine;AKOS005265330;AB38778;CS-0365608;F80124

Chemical Property of 3-(3-Chlorophenyl)-N-methylpropan-1-amine

Chemical Property:

• Boiling Point: 260.8±23.0 °C(Predicted)
• PKA: 10.52±0.10(Predicted)
• Density: 1.043±0.06 g/cm3(Predicted)
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 183.0814771
• Heavy Atom Count: 12
• Complexity: 116

Purity/Quality:

99% ^*data from raw suppliers

[3-(3-CHLORO-PHENYL)-PROPYL]-METHYL-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNCCCC1=CC(=CC=C1)Cl
• Uses: 3-Chloro-N-methyl-benzenepropanamine is used to prepare tetrahydroquinolines and benzomorpholines .

Technology Process of 3-(3-Chlorophenyl)-N-methylpropan-1-amine

There total 3 articles about 3-(3-Chlorophenyl)-N-methylpropan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(3-chloro-phenyl)-propionic acid methylamide (103754-14-9) → [3-(3-chloro-phenyl)-propyl]-methyl-amine (103275-33-8)

Guidance literature:

With lithium aluminium tetrahydride;

Reference yield:

3-chlorohydrocinnamic acid (21640-48-2) → [3-(3-chloro-phenyl)-propyl]-methyl-amine (103275-33-8)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂

2: aqueous NaOH

3: LiAlH₄

With sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride;

Reference yield:

3-(3-chlorophenyl)propionyl chloride (40478-50-0) → [3-(3-chloro-phenyl)-propyl]-methyl-amine (103275-33-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH

2: LiAlH₄

With sodium hydroxide; lithium aluminium tetrahydride;

upstream raw materials:

3-(3-chloro-phenyl)-propionic acid methylamide

3-chlorohydrocinnamic acid

3-(3-chlorophenyl)propionyl chloride

Downstream raw materials:

N-methyl-1,2,3,4-tetrahydroquinoline

methyl-(3-phenyl-propyl)-amine