methyl (p-nitrophenyl)phosphonic acid

Base Information

• Chemical Name: methyl (p-nitrophenyl)phosphonic acid
• CAS No.: 98276-53-0
• Molecular Formula: C₇H₈NO₅P
• Molecular Weight: 217.118
• Mol file: 98276-53-0.mol

Synonyms:methyl (p-nitrophenyl)phosphonic acid

Chemical Property of methyl (p-nitrophenyl)phosphonic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl (p-nitrophenyl)phosphonic acid

There total 2 articles about methyl (p-nitrophenyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 4-nitropheylphosphonic acid (2175-86-2) → methyl (p-nitrophenyl)phosphonic acid (98276-53-0)

Guidance literature:

With dicyclohexyl-carbodiimide;

DOI:10.1021/ja01570a073

Reference yield:

4-nitropheylphosphonic acid (2175-86-2) + trimethyl orthoformate (149-73-5) → methyl (p-nitrophenyl)phosphonic acid (98276-53-0)

Guidance literature:

With sodium hydroxide; Yield given. Multistep reaction; 1.) 90 deg C, 20 h, 2.) MeOH, RT, 80 h;

DOI:10.1021/ja00001a043

Reference yield:

methyl (p-nitrophenyl)phosphonic acid (98276-53-0) → (S)-2-{(S)-2-[Hydroxy-(4-nitro-phenyl)-phosphinoyloxy]-4-methyl-pentanoylamino}-4-methyl-pentanoic acid

Guidance literature:

Multi-step reaction with 2 steps

1: bis(2-oxo-3-oxazolidinyl)phosphonic chloride (BOP-Cl), triethylamine / acetonitrile / 16 h / Heating

2: 1 N aq. LiOH / acetonitrile / 80 h / Ambient temperature

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In acetonitrile;

DOI:10.1021/ja00001a043

upstream raw materials:

methanol

4-nitropheylphosphonic acid

trimethyl orthoformate

Downstream raw materials:

(4-nitro-phenyl)-phosphonic acid methyl ester-[2]pyridylamide

(4-amino-phenyl)-phosphonic acid monomethyl ester

(4-amino-phenyl)-phosphonic acid methyl ester-[2]pyridylamide

Refernces