3,4-Dibromofuran

Base Information

• Chemical Name: 3,4-Dibromofuran
• CAS No.: 32460-02-9
• Molecular Formula: C4H2Br2O
• Molecular Weight: 225.867
• Hs Code.: 2932190090
• European Community (EC) Number: 836-237-9
• DSSTox Substance ID: DTXSID60348915
• Nikkaji Number: J88.801J
• Wikidata: Q72464395
• Mol file: 32460-02-9.mol

Synonyms:3,4-dibromofuran;32460-02-9;furan, 3,4-dibromo-;MFCD01318995;3,4-bis(bromanyl)furan;SCHEMBL2084015;DTXSID60348915;GEO-03971;AKOS015835701;SB61169;CS-11510;SY023104;AM20080680;CS-0157802;D5313;FT-0639027;EN300-102247;A821283

Chemical Property of 3,4-Dibromofuran

Chemical Property:

• Vapor Pressure: 1.4mmHg at 25°C
• Melting Point: 6°C(lit.)
• Refractive Index: 1.562
• Boiling Point: 177.5 °C at 760 mmHg
• Flash Point: 61.1 °C
• PSA: 13.14000
• Density: 2.159 g/cm³
• LogP: 2.80460
• Storage Temp.: Refrigerated.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 225.84519
• Heavy Atom Count: 7
• Complexity: 58.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,4-Dibromofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CO1)Br)Br
• Uses: 3,4-Dibromofuran is a useful synthetic intermediate. It is used in the preparation of norbormide analogs. It is also used in the preparation of 5,5'',6,6''-tetrahydroxy-3,3''-biindolyl as a potent antioxidant found in beetroot.

Technology Process of 3,4-Dibromofuran

There total 6 articles about 3,4-Dibromofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,3-dibromo-but-2-ene-1,4-diol (3234-02-4) → 3,4-dibromofuran (32460-02-9)

Guidance literature:

With potassium dichromate; sulfuric acid; In hexane; water; at 85 ℃; for 6h; Heating;

DOI:10.1080/00397919808003078

Reference yield: 56.0%

Trans-2,3-dibromo-2-butene-1,4-diol (21285-46-1) → 3,4-dibromofuran (32460-02-9)

Guidance literature:

With potassium dichromate; sulfuric acid; In water; at 110 ℃; for 2h;

DOI:10.1016/j.tet.2004.02.043

Reference yield:

1,4-dihydroxybut-2-yne (110-65-6) → 3,4-dibromofuran (32460-02-9)

Guidance literature:

With potassium dichromate; bromine; Multistep reaction; 1.) chloroform;

DOI:10.1016/0022-2860(94)08494-3

upstream raw materials:

3,4-dibromo-furan-2-carboxylic acid

2,3-dibromo-but-2-ene-1,4-diol

1,4-dihydroxybut-2-yne

Trans-2,3-dibromo-2-butene-1,4-diol

Downstream raw materials:

3-bromo-4-methylfuran

3-bromofurane

3,4-dibromo-2-phenylsulfanyl-furan

3,4-bis(4,5-di(benzyloxy)-2-nitrophenyl)furan

Refernces

• 1、 Rennison, David,Bova, Sergio,Cavalli, Maurizio,Ricchelli, Fernanda,Zulian, Alessandra,Hopkins, Brian,Brimble, Margaret A.. "Synthesis and activity studies of analogues of the rat selective toxicant norbormide". . p. 2963 - 2974. Retrieved 2008/02/01.
• 2、 Kraus, George A.,Wang, Xuemei. "An improved synthesis of 3-substituted furans from substituted butene- 1,4-diols". . p. 1093 - 1096. Retrieved 2007/10/03.