benzyl 2,2-dichloroacetate

Base Information

• Chemical Name: benzyl 2,2-dichloroacetate
• CAS No.: 37079-09-7
• Molecular Formula: C₉H₈Cl₂O₂
• Molecular Weight: 219.067
• Mol file: 37079-09-7.mol

Synonyms:benzyl 2,2-dichloroacetate

Chemical Property of benzyl 2,2-dichloroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of benzyl 2,2-dichloroacetate

There total 4 articles about benzyl 2,2-dichloroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

benzyl 2,2,2-trichloroacetate (26827-38-3) → benzyl 2,2-dichloroacetate (37079-09-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 28 ℃; for 60h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.9b03848

Reference yield: 71.0%

benzyl diazoacetate (52267-51-3) → Benzyl chloroacetate (140-18-1) + benzyl 2,2-dichloroacetate (37079-09-7)

Guidance literature:

With pyridine; (Dichloroiodo)benzene; In dichloromethane; at 20 ℃; for 0.0833333h;

DOI:10.1021/ja408678p

Reference yield:

dichloro-acetic acid (79-43-6) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2,2-dichloroacetate (37079-09-7)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

dichloro-acetic acid

benzyl alcohol

benzyl diazoacetate

benzyl 2,2,2-trichloroacetate

Refernces

• 1、 Tao, Jason,Tran, Richard,Murphy, Graham K.. "Dihaloiodoarenes: α,α-dihalogenation of phenylacetate derivatives". supporting information. p. 16312 - 16315. Retrieved 2013/12/04.