5-Chloropyrazolo[1,5-a]pyrimidine

Base Information

• Chemical Name: 5-Chloropyrazolo[1,5-a]pyrimidine
• CAS No.: 29274-24-6
• Molecular Formula: C6H4ClN3
• Molecular Weight: 153.571
• Hs Code.: 2933990090
• Mol file: 29274-24-6.mol

Synonyms:5-Chloropyrazolo[1,5-a]pyrimidine;5-Chlor-pyrazolo<1,5-a>pyrimidin;

Chemical Property of 5-Chloropyrazolo[1,5-a]pyrimidine

Chemical Property:

• Refractive Index: 1.713
• PKA: -0.49±0.30(Predicted)
• PSA: 30.19000
• Density: 1.514 g/cm³
• LogP: 1.38270
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%, ^*data from raw suppliers

5-Chloropyrazolo[1,5-a]pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5-Chloropyrazolo[1,5-a]pyrimidine was used in the preparation of β-substituted biarylphenylalanine amides as selective amino amide dipeptidyl peptidase IV inhibitors for treatment of type 2 diabetes.

Technology Process of 5-Chloropyrazolo[1,5-a]pyrimidine

There total 4 articles about 5-Chloropyrazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

pyrazolo[1,5-a]pyrimidine-5-ol (29274-22-4) → 5-chloropyrazolo[1,5-a]pyrimidine (29274-24-6)

Guidance literature:

With trichlorophosphate; In acetonitrile; at 85 ℃; for 2h; Large scale;

Reference yield: 80.0%

4H,5H-pyrazolo[1,5-a]pyrimidine-5-one (29274-22-4) → 5-chloropyrazolo[1,5-a]pyrimidine (29274-24-6)

Guidance literature:

With trichlorophosphate; at 120 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112770

Reference yield:

5-bromopyrazolo[1,5-a]pyrimidine (1159981-95-9) → 5-chloropyrazolo[1,5-a]pyrimidine (29274-24-6)

Guidance literature:

With trichlorophosphate;

upstream raw materials:

pyrazolo[1,5-a]pyrimidine-5-ol

4H,5H-pyrazolo[1,5-a]pyrimidine-5-one

5-bromopyrazolo[1,5-a]pyrimidine

Downstream raw materials:

5-iodo-pyrazolo[1,5-a]pyrimidine

3-pyrazolo[1,5-a]pyrimidin-5-ylethynyl-benzonitrile

(R)-5-(4,4-difluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine

Refernces

• 1、 -. "Method for efficiently synthesizing 5-chloropyrazolo[1,5-a]pyrimidine". Paragraph 0025; 0026; 0029. . Retrieved 2019/02/04.
• 2、 -. "Heterocyclic Compound". Paragraph 1805; 1808; 1809; 1819; 1822; 1823. . Retrieved 2018/06/15.