4-BROMO-2,3,5,6-TETRAFLUOROBENZONITRILE

Base Information

• Chemical Name: 4-BROMO-2,3,5,6-TETRAFLUOROBENZONITRILE
• CAS No.: 17823-40-4
• Molecular Formula: C7BrF4N
• Molecular Weight: 253.981
• Hs Code.: 2926907090
• Mol file: 17823-40-4.mol

Synonyms:4-Bromo-2,3,5,6-tetrafluorobenzonitrile;4-Bromotetrafluorobenzonitrile;

Chemical Property of 4-BROMO-2,3,5,6-TETRAFLUOROBENZONITRILE

Chemical Property:

• Vapor Pressure: 0.274mmHg at 25°C
• Melting Point: 77-79 °C
• Refractive Index: 1.508
• Boiling Point: 203.7 °C at 760mmHg
• Flash Point: 77 °C
• PSA: 23.79000
• Density: 1.91 g/cm³
• LogP: 2.87718
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Bromo-2,3,5,6-tetrafluorobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn'Xi
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Bromo-2,3,5,6-tetrafluorobenzonitrile may be used in chemical synthesis.

Technology Process of 4-BROMO-2,3,5,6-TETRAFLUOROBENZONITRILE

There total 9 articles about 4-BROMO-2,3,5,6-TETRAFLUOROBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-amino-2,3,5,6-tetrafluorobenzonitrile (17823-38-0) + hydrogen fluoride (7664-39-3,12381-92-9,32057-09-3,74835-82-8) + hydrogen bromide (10035-10-6,12258-64-9) + copper(I) bromide (7787-70-4) → 4-Bromo-2,3,5,6-tetrafluorobenzonitrile (17823-40-4)

Guidance literature:

With NaNO₂; react with NaNO2 45 min, then in HF at 0°C, adding to soln. of CuBr in 48% HBr at 0°C, 3 h;

Reference yield: 55.0%

Pentafluorobenzonitrile (773-82-0) + lithium bromide (7550-35-8) → 4-Bromo-2,3,5,6-tetrafluorobenzonitrile (17823-40-4)

Guidance literature:

In further solvent(s); refluxing in N-methyl-2-pirrolydone 0.5 h; distn.;

DOI:10.1039/J39710001343

Reference yield:

Pentafluorobenzonitrile (773-82-0) → 4-Bromo-2,3,5,6-tetrafluorobenzonitrile (17823-40-4)

Guidance literature:

Pentafluorobenzonitrile; With tin(ll) chloride; zinc; In N,N-dimethyl-formamide; sonication;

With bromine; In N,N-dimethyl-formamide; for 1h;

DOI:10.1016/S0040-4039(00)00527-X

upstream raw materials:

Pentafluorobenzonitrile

lithium bromide

4-amino-2,3,5,6-tetrafluorobenzonitrile

hydrogen fluoride

Downstream raw materials:

ethyl 2-cyano-2-(4-cyanoperfluorophenyl)acetate

1,1’-(dicyano)-2,2’,3,3’,5,5’,6,6’-octafluoro-4,4’-biphenyl

1-(triethylgermyl)-4-cyanotetrafluorobenzene

Refernces