Boronic acid, (3-fluoro-2-methoxyphenyl)- (9CI)

Base Information

• Chemical Name: Boronic acid, (3-fluoro-2-methoxyphenyl)- (9CI)
• CAS No.: 762287-59-2
• Molecular Formula: C7H8BFO3
• Molecular Weight: 169.948
• Hs Code.: 2931900090
• Mol file: 762287-59-2.mol

Synonyms:Boronicacid, (3-fluoro-2-methoxyphenyl)- (9CI);2-Methoxy-3-fluorobenzeneboronic acid;3-Fluoro-2-methoxyphenylboronic acid;[3-Fluoro-2-(methyloxy)phenyl]boronicacid;(3-Fluoro-2-methoxyphenyl)boronic acid;boronic acid, B-(3-fluoro-2-methoxyphenyl)-;3-Fluoro-2-methoxybenzeneboronic acid;3-Fluoro-2-methoxyphenylboronic acid;3-Fluoro-2-methoxyphenylboronicacid;

Chemical Property of Boronic acid, (3-fluoro-2-methoxyphenyl)- (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.504
• Boiling Point: 330.713 °C at 760 mmHg
• PKA: 7.52±0.58(Predicted)
• Flash Point: 153.81 °C
• PSA: 49.69000
• Density: 1.265 g/cm³
• LogP: -0.48590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Fluoro-2-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of Boronic acid, (3-fluoro-2-methoxyphenyl)- (9CI)

There total 1 articles about Boronic acid, (3-fluoro-2-methoxyphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H12BFO3 → (3-fluoro-2-methoxyphenyl)boronic acid (762287-59-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1016/S0960-894X(02)00460-2

Reference yield: 95.0%

6-chloro-4-phenyl-pyridazin-3-yl-amine (944468-99-9) + (3-fluoro-2-methoxyphenyl)boronic acid (762287-59-2) → 6-(3-fluoro-2-methoxyphenyl)-4-phenylpyridazin-3-amine

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; In 1,4-dioxane; water; at 110 ℃; for 12h;

Reference yield: 92.0%

1-bromo-2-chlorocyclohexene + (3-fluoro-2-methoxyphenyl)boronic acid (762287-59-2) → 1-chloro-2-(3′-fluoro-2′-methoxyphenyl)cyclohexene

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium carbonate; In 1,4-dioxane; at 110 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.051

Downstream raw materials:

1-fluoro-2-methoxy-3-(1-methylenepropyl)benzene

C₁₈H₁₈FN₅O₂

C₁₉H₁₅F₄N₃O₃

C₁₇H₁₆FNO₄

Refernces