3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone

Base Information

• Chemical Name: 3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone
• CAS No.: 79580-95-3
• Molecular Formula: C₃₁H₄₆N₂O₆S
• Molecular Weight: 574.782
• Mol file: 79580-95-3.mol

Synonyms:3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone

Chemical Property of 3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone

There total 1 articles about 3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid (2458-08-4) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone (79580-95-3)

Guidance literature:

In acetic acid; for 12h; Ambient temperature;

DOI:10.1021/jo00136a030

Reference yield:

3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone (79580-95-3) → chenodeoxycholic acid (474-25-9)

Guidance literature:

With sodium tetrahydroborate; In acetic acid; for 3h; Ambient temperature;

DOI:10.1021/jo00136a030

Reference yield:

3α,7α-dihydroxy-12-oxocholanic acid tosylhydrazone (79580-95-3) → ursodeoxycholic acid (128-13-2)

Guidance literature:

Multi-step reaction with 5 steps

1: NaBH₄ / acetic acid / 3 h / Ambient temperature

2: HCl

3: pyridine / benzene

4: pyridine / Ambient temperature

5: KO₂/18-crown-6 ether / dimethylsulfoxide / 3 h

With pyridine; hydrogenchloride; potassium superoxide; sodium tetrahydroborate; 18-crown-6 ether; In acetic acid; dimethyl sulfoxide; benzene;

DOI:10.1021/jo00136a030

upstream raw materials:

3α,7α-dihydroxy-12-oxo-5β-cholan-24-oic acid

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

chenodeoxycholic acid

ursodeoxycholic acid

Refernces