H-D-SER-OET HCL

Base Information

• Chemical Name: H-D-SER-OET HCL
• CAS No.: 104055-46-1
• Molecular Formula: C₅H₁₁NO₃*(x)ClH
• Molecular Weight: 169.61
• Hs Code.: 2922509090
• Mol file: 104055-46-1.mol

Synonyms:D-Serine,ethyl ester, hydrochloride (9CI);

Chemical Property of H-D-SER-OET HCL

Chemical Property:

• PSA: 72.55000
• LogP: 0.37140
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

D-Serine ethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Serine Ethyl Ester Hydrochloride is a modulator of NMDA receptors. Also, it is a reagent in the synthesis of (+)-tetrahydropseudodistomin, a calmodulin antagonist pseudodistomin A and B.

Technology Process of H-D-SER-OET HCL

There total 10 articles about H-D-SER-OET HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + L-serin (56-45-1,83245-15-2) → L-serine ethyl ester hydrochloride (26348-61-8,104055-46-1)

Guidance literature:

With thionyl chloride; at 0 ℃; Inert atmosphere;

Reference yield: 95.0%

ethanol (64-17-5) + N-Boc-DL-serine (3850-40-6) → serine ethyl ester hydrochloride (3940-27-0,104055-46-1)

Guidance literature:

With thionyl chloride;

DOI:10.1039/d1cc01285a

Reference yield: 95.0%

→ serine ethyl ester hydrochloride (3940-27-0,104055-46-1)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃;

upstream raw materials:

ethanol

L-serin

(S)-ethyl N-trifluoroacetyl-O-(m-chlorobenzoyl)serinate

acid chloride of (2S)-α-ethyl N-trifluoroacetylaspartate

Downstream raw materials:

benzyloxycarbonylserine ethyl ester

Refernces

• 1、 Sun, Bin,Dong, Yue,An, Yunfei,Liu, Min,Han, Jun,Zhao, Liyu,Liu, Xinyong. "Design, synthesis and bioactivity evaluation of novel arylalkene-amide derivatives as dual-target antifungal inhibitors". . . Retrieved 2020.
• 2、 Pang, Chaohai,Luo, Jinhui,Liu, Chunhua,Wu, Xuejin,Wang, Dingyong. "Synthesis and Biological Evaluation of a Series of Novel Celastrol Derivatives with Amino Acid Chain". . . Retrieved 2018.
• 3、 An, Yunfei,Dong, Yue,Liu, Min,Han, Jun,Zhao, Liyu,Sun, Bin. "Novel naphthylamide derivatives as dual-target antifungal inhibitors: Design, synthesis and biological evaluation". . . Retrieved 2021.
• 4、 Zhao, Dongmei,Zhao, Shizhen,Zhao, Liyu,Zhang, Xiangqian,Wei, Peng,Liu, Chunchi,Hao, Chenzhou,Sun, Bin,Su, Xin,Cheng, Maosheng. "Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies". . p. 750 - 758. Retrieved 2017.
• 5、 Smirnova, E. A.,Davidovich, Yu. A.,Chernyavskaya, M. A.,Belova, A. S.,Rogozhin, S. V.. "SYNTHESIS AND ANTIMICROBIAL PROPERTIES OF ALKYL ESTERS OF O-ACYL SERINE". . p. 632 - 636. Retrieved 1986.
• 6、 Lu, Guan-Han,Huang, Tzu-Chia,Hsueh, Hsiao-Chin,Yang, Shin-Cherng,Cho, Ting-Wei,Chou, Ho-Hsuan. "NovelN-transfer reagent for converting α-amino acid derivatives to α-diazo compounds". supporting information. p. 4839 - 4842. Retrieved 2021/05/25.