Z-THR-NHNH2

Base Information

• Chemical Name: Z-THR-NHNH2
• CAS No.: 49706-30-1
• Molecular Formula: C12H17 N3 O4
• Molecular Weight: 267.285
• Mol file: 49706-30-1.mol

Synonyms:Threonine,N-carboxy-, N-benzyl ester, hydrazide (7CI)

Chemical Property of Z-THR-NHNH2

Chemical Property:

• PSA: 113.68000
• LogP: 1.13420
• Storage Temp.: -15°C

Purity/Quality:

98%min ^*data from raw suppliers

Z-L-threonine hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-THR-NHNH2

There total 4 articles about Z-THR-NHNH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate (57224-63-2) → Cbz-L-threonine hydrazide (49706-30-1)

Guidance literature:

With hydrazine hydrate; In methanol;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → Cbz-L-threonine hydrazide (49706-30-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CHCl₃

2: N₂H₄*H₂O / methanol

With hydrazine hydrate; triethylamine; In methanol; chloroform;

Reference yield:

→ N-benzyloxycarbonyl-threonine hydrazide (49706-30-1,67580-91-0,108038-71-7)

Guidance literature:

With ethanol; hydrazine hydrate;

upstream raw materials:

methyl (2S,3R)-2-(benzyloxycarbonylamino)-3-hydroxybutyrate

benzyl chloroformate

Downstream raw materials:

Z-Thr-Phe-OMe

(5t-methyl-2-oxo-oxazolidin-4r-yl)-carbamic acid benzyl ester

N-benzyloxycarbonyl-L-threonyl-glycine

Z-Thr-Pro-Ile-Leu-Pro-Gln-OtBu

Refernces