L-Valine tert.butyl amide

Base Information

• Chemical Name: L-Valine tert.butyl amide
• CAS No.: 72669-49-9
• Molecular Formula: C₉H₂₀N₂O
• Molecular Weight: 172.271
• Mol file: 72669-49-9.mol

Synonyms:L-Valine tert.butyl amide

Chemical Property of L-Valine tert.butyl amide

Chemical Property:

• PSA: 55.12000
• LogP: 1.97560

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Valine tert.butyl amide

There total 10 articles about L-Valine tert.butyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-tert-butyl 1-(tert-butylamino)-3-methyl-1-oxobutan-2-ylcarbamate (86154-20-3) → (S)-2-amino-N-tert-butyl-3-methylbutanamide (3057-81-6,69981-34-6,72669-49-9,144902-47-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0957-4166(01)00352-4

Reference yield:

(S)-N-(benzyloxycarbonyl)valine (1149-26-4) → (S)-2-amino-N-tert-butyl-3-methylbutanamide (3057-81-6,69981-34-6,72669-49-9,144902-47-6)

Guidance literature:

With hydrogen; palladium; In methanol;

Reference yield:

N-carbobenzoxy-L-valyl-tert-butylamide (61274-17-7) → (S)-2-amino-N-tert-butyl-3-methylbutanamide (3057-81-6,69981-34-6,72669-49-9,144902-47-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 5h; Ambient temperature;

upstream raw materials:

(S)-N-(benzyloxycarbonyl)valine

N-carbobenzoxy-L-valyl-tert-butylamide

(S)-tert-butyl 1-(tert-butylamino)-3-methyl-1-oxobutan-2-ylcarbamate

t-Boc-L-valine

Downstream raw materials:

(S)-1-tert-butyl-3-[(R)-3-hydroxy-3-phenylpropanoyl]-4-isopropylimidazolidin-2-one

{(R)-1-Benzyl-3-[(S)-2-((S)-1-tert-butylcarbamoyl-2-methyl-propylcarbamoyl)-pyrrolidin-1-yl]-1-[1,3]dithiolan-2-yl-propyl}-carbamic acid allyl ester

SDZ 282314

Refernces

• 1、 Khatik, Gopal L.,Kumar, Varun,Nair, Vipin A.. "Reversal of selectivity in acetate aldol reactions of N-acetyl-(S)-4- isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one". supporting information; experimental part. p. 2442 - 2445. Retrieved 2012/07/03.
• 2、 -. "Methods and compositions for treating amyloid-related diseases". Page/Page column 136. . Retrieved 2010/11/24.