H-D-PHE-NH2 HCL

Base Information

• Chemical Name: H-D-PHE-NH2 HCL
• CAS No.: 71666-94-9
• Molecular Formula: C9H13ClN2O
• Molecular Weight: 200.668
• Hs Code.: 2922498590
• Mol file: 71666-94-9.mol

Synonyms:D-Phe-NH2*HCl; H-D-Phe-NH2*HCl; D-Phenylalaninamide hydrochloride; (R)-2-amino-3-phenylpropanamide hydrochloride; d-phe-nh2Cl; (R)-phenylalaninamide hydrochloride; (R)-phenylalanine amide hydrochloride; (R)-AlaninaMide hydrochloride; HCl-H-D-Phe-NH2; D-PHENYLALANINE AMIDE HYDROCHLORIDE; 查看更多英文别名 收起

Chemical Property of H-D-PHE-NH2 HCL

Chemical Property:

• PSA: 69.11000
• LogP: 2.24430
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

D-Phenylalanine amide hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-PHE-NH2 HCL

There total 7 articles about H-D-PHE-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

D-phenylalanine methyl ester hydrochloride (13033-84-6) → (R)-2-amino-3-phenylpropanamide hydrochloride (71666-94-9)

Guidance literature:

With ammonia; In methanol; at 20 ℃; for 20h; Cooling with ice; Sealed tube;

Reference yield: 81.0%

(R)-tert-butyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate (129095-62-1,35150-06-2) → (R)-2-amino-3-phenylpropanamide hydrochloride (71666-94-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 0.5h; Ambient temperature;

Reference yield:

2-(1,3-dicyano-5-isopropenyl-2-methyl-cyclohexylamino)-3-phenyl-propionamide → (S)-2-amino-3-phenylpropionamide hydrochloride (65864-22-4) + (R)-2-amino-3-phenylpropanamide hydrochloride (71666-94-9)

Guidance literature:

With hydrogenchloride; In methanol; water; at 50 ℃; for 4h; pH=1; Title compound not separated from byproducts;

DOI:10.1002/ejoc.200600294

upstream raw materials:

(R)-tert-butyl (1-amino-1-oxo-3-phenylpropan-2-yl)carbamate

(-)-1-<(1-cyano-2-phenylethyl)amino>-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

Phenylalanine

D-phenylalanine methyl ester hydrochloride

Downstream raw materials:

Z-Asn-D-Phe-NH₂

[(S)-1-Carbamoyl-2-((R)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-ethyl]-carbamic acid benzyl ester

Moz-Phe-D-Phe-NH₂

Refernces

• 1、 -. "MU OPIOID RECEPTOR MODULATORS". Paragraph 0421; 0422. . Retrieved 2018/07/31.
• 2、 Yasukawa, Kazuyuki,Asano, Yasuhisa. "Enzymatic synthesis of chiral phenylalanine derivatives by a dynamic kinetic resolution of corresponding amide and nitrile substrates with a multi-enzyme system". . p. 3327 - 3332. Retrieved 2013/01/15.