Methyl 2-(2-aminoacetamido)acetate hydrochloride

Base Information

• Chemical Name: Methyl 2-(2-aminoacetamido)acetate hydrochloride
• CAS No.: 2776-60-5
• Molecular Formula: C5H10N2O3·ClH
• Molecular Weight: 182.607
• Hs Code.: 2924199090
• European Community (EC) Number: 631-069-0
• DSSTox Substance ID: DTXSID10515690
• Mol file: 2776-60-5.mol

Synonyms:2776-60-5;H-Gly-Gly-OMe.HCl;methyl 2-(2-aminoacetamido)acetate hydrochloride;glycylglycine methyl ester hydrochloride;H-Gly-Gly-OMe HCl;methyl 2-[(2-aminoacetyl)amino]acetate;hydrochloride;Glycylglycine methyl ester HCl;MFCD00039056;Methyl 2-(2-aminoacetamido)acetate HCl;Glycine, glycyl-, methyl ester, hydrochloride (1:1);METHYL ((AMINOACETYL)AMINO)ACETATE HYDROCHLORIDE;SCHEMBL919797;DTXSID10515690;RZOAGVGJBLVHIZ-UHFFFAOYSA-N;Methyl glycylglycinate hydrochloride;AKOS016014371;DS-6171;glycyl glycine methyl ester hydrochloride;glycyl-glycine methyl ester hydrochloride;SY102049;CS-0150654;FT-0634480;EN300-192601;H11329;Methyl glycylglycinate--hydrogen chloride (1/1);J-016879;5-Amino-1-(4-methoxyphenyl)-1H-pyrazole-4-carboxylicacid;Glycylglycine methyl ester hydrochloride (H-Gly-Gly-OMe.HCl)

Chemical Property of Methyl 2-(2-aminoacetamido)acetate hydrochloride

Chemical Property:

• Vapor Pressure: 0.00019mmHg at 25°C
• Boiling Point: 323.5 °C at 760 mmHg
• Flash Point: 149.4 °C
• PSA: 81.42000
• LogP: 0.12750
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 182.0458199
• Heavy Atom Count: 11
• Complexity: 135

Purity/Quality:

98% ^*data from raw suppliers

H-Gly-Gly-OMeHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CNC(=O)CN.Cl

Technology Process of Methyl 2-(2-aminoacetamido)acetate hydrochloride

There total 5 articles about Methyl 2-(2-aminoacetamido)acetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + glycylglycine (556-50-3) → glycylglycine methyl ester hydrochloride (2776-60-5)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 3h;

DOI:10.1039/c6ob00950f

Reference yield: 94.0%

N-tert-butoxycarbonyl glycyl glycine methyl ester (53487-98-2) → glycylglycine methyl ester hydrochloride (2776-60-5)

Guidance literature:

With hydrogenchloride; In acetic acid; for 0.5h;

DOI:10.1002/jlac.198319831002

Reference yield:

methyl 2-(2-phthalimidoacetamido)acetate (5033-17-0) → glycylglycine methyl ester hydrochloride (2776-60-5)

Guidance literature:

methyl 2-(2-phthalimidoacetamido)acetate; In ethanol; at 100 ℃; for 2h;

With hydrogenchloride; In water;

DOI:10.1016/j.biopha.2017.01.160

upstream raw materials:

methanol

glycylglycine

N-tert-butoxycarbonyl glycyl glycine methyl ester

2,2-dimethoxy-propane

Downstream raw materials:

triglycine methyl ester

Ac-Ala-Gly-Gly-OMe

Refernces

• 1、 Nakamura,Asai,Nishida,Sasaki. "A novel prodrug of salicylic acid, salicylic acid-glycylglycine conjugate, utilizing the hydrolysis in rabbit intestinal microorganisms". . p. 713 - 716. Retrieved 1992.
• 2、 Maji,Samanta. "Novel thiazolidinedione-5-acetic-acid-peptide hybrid derivatives as potent antidiabetic and cardioprotective agents". . p. 1163 - 1172. Retrieved 2017/02/23.