H-D-LEU-OBZL P-TOSYLATE

Base Information

• Chemical Name: H-D-LEU-OBZL P-TOSYLATE
• CAS No.: 17664-93-6
• Molecular Formula: C20H27NO5S
• Molecular Weight: 393.504
• Hs Code.: 2922499990
• Mol file: 17664-93-6.mol

Synonyms:D-Leucine benzyl ester tosylate;D-Leu.OBzl.Tos;H-D-Leu-OBzl·TosOH;

Chemical Property of H-D-LEU-OBZL P-TOSYLATE

Chemical Property:

• Melting Point: 158 °C
• Refractive Index: -5 ° (C=2, DMF)
• PSA: 115.07000
• LogP: 5.12600
• Storage Temp.: Store at RT.
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

H-D-Leu-obzltos ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-LEU-OBZL P-TOSYLATE

There total 1 articles about H-D-LEU-OBZL P-TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ (R)-benzyl 2-amino-4-methylpentanoate p-toluenesulfonate salt (17664-93-6)

Guidance literature:

Reference yield: 100.0%

acetic anhydride (108-24-7) + (R)-benzyl 2-amino-4-methylpentanoate p-toluenesulfonate salt (17664-93-6) → D-LeuAc-OBn (211988-64-6)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja106118w

Reference yield: 96.0%

(R)-benzyl 2-amino-4-methylpentanoate p-toluenesulfonate salt (17664-93-6) + N-tert-butoxycarbonyl-L-α-allylproline (144085-23-4) → N-[2-allyl-N-(tert-butoxycarbonyl)-L-prolyl]-D-leucine benzyl ester (387823-63-4)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 17h;

DOI:10.1016/j.tet.2004.04.052

Downstream raw materials:

(R)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-tert-butoxycarbonylamino-propionylamino]-4-methyl-pentanoic acid benzyl ester

Z-(2S,3R)-AHPA-(R)-Leu-OBzl

(R)-2-((2R,3R)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyrylamino)-4-methyl-pentanoic acid benzyl ester

Z-(2S,3S)-AHPA-(R)-Leu-OBzl

Refernces

• 1、 -. "Analgesic compounds". . . Retrieved 2008/06/13.