Z-BETA-ALA-OSU

Base Information

• Chemical Name: Z-BETA-ALA-OSU
• CAS No.: 53733-97-4
• Molecular Formula: C15H16 N2 O6
• Molecular Weight: 320.302
• Hs Code.: 2925190090
• Mol file: 53733-97-4.mol

Synonyms:Z-BETA-ALANINE HYDROXYSUCCINIMIDE ESTER;Z-BETA-ALANINE N-HYDROXYSUCCINIMIDE ESTER;Z-BETA-ALANINE-OSU;Z-BETA-ALA-OSU;Z-β-Alanine N-hydroxysuccinimide ester;Z-B-ALANINE HYDROXYSUCCINIMIDESTER;CBZ-.BETA.-ALANINE N-HYDROXYSUCCINIMIDE ESTER;Z-b-Ala-OSu

Chemical Property of Z-BETA-ALA-OSU

Chemical Property:

• PSA: 102.01000
• LogP: 1.23890
• Storage Temp.: -15°C

Purity/Quality:

98%Min ^*data from raw suppliers

Z-beta-alanine N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-BETA-ALA-OSU

There total 3 articles about Z-BETA-ALA-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + 3-(benzyloxycarbonylamino)propanoic acid (2304-94-1) → N-benzyloxycarbonyl-3-aminopropionic acid succinimide ester (53733-97-4)

Guidance literature:

With polymer supported ethyl dimethylaminopropylcarbodiimide; In chloroform; N,N-dimethyl-formamide; for 14h;

DOI:10.1016/0040-4039(95)01761-6

Reference yield: 80.0%

→ N-benzyloxycarbonyl-3-aminopropionic acid succinimide ester (53733-97-4)

Guidance literature:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-3-aminopropionic acid succinimide ester (53733-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ag.NaOH / stirred overnight

2: DCC / dioxane / stirred overnight

With sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane;

DOI:10.1002/jhet.5570230348

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

3-(benzyloxycarbonylamino)propanoic acid

benzyl chloroformate

Downstream raw materials:

(2-{[(2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethyl]-carbamoyl}-ethyl)-carbamic acid benzyl ester

[(R)-2-(3-Benzyloxycarbonylamino-propionylamino)-3-(4-bromo-benzylsulfanyl)-propionylamino]-acetic acid

(±)-Cbz-βAla-Phe-OH

spiro[(4-ethyl-7,8-dihydropyrano[3,2-g]chromen-2-one)-8,1'-cyclohexane] N-(N-benzyloxycarbonyl-β-alanyl)hydrazone

Refernces

• 1、 -. "Novel compositions for the delivery of negatively charged molecules". . . Retrieved 2008/06/13.
• 2、 Adamczyk, Maciej,Fishpaugh, Jeffrey R.,Mattingly, Phillip G.. "An Easy Preparation of Hapten Active Esters via Solid Supported EDAC". . p. 8345 - 8346. Retrieved 2007/10/02.