BOC-11-AMINOUNDECANOIC ACID

Base Information

• Chemical Name: BOC-11-AMINOUNDECANOIC ACID
• CAS No.: 10436-25-6
• Molecular Formula: C16H31 N O4
• Molecular Weight: 301.426
• Hs Code.: 2924199090
• European Community (EC) Number: 626-987-3
• DSSTox Substance ID: DTXSID60401054
• Nikkaji Number: J409.505G
• Wikidata: Q82204114
• Mol file: 10436-25-6.mol

Synonyms:Undecanoicacid, 11-(carboxyamino)-, 11-tert-butyl ester (7CI); Undecanoic acid,11-(carboxyamino)-, N-tert-butyl ester (8CI);11-(tert-Butoxycarbonylamino)undecanoic acid;11-[N-(tert-Butoxycarbonyl)amino]undecanoic acid;N-(tert-Butoxycarbonyl)-11-aminoundecanoic acid

Chemical Property of BOC-11-AMINOUNDECANOIC ACID

Chemical Property:

• Melting Point: 67-68 °C
• Boiling Point: 441.9±18.0 °C(Predicted)
• PKA: 4.78±0.10(Predicted)
• PSA: 75.63000
• Density: 1.006±0.06 g/cm3(Predicted)
• LogP: 4.49750
• Storage Temp.: 2-8°C
• Solubility.: soluble in Methanol
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 13
• Exact Mass: 301.22530847
• Heavy Atom Count: 21
• Complexity: 297

Purity/Quality:

98%,99%, ^*data from raw suppliers

Boc-11-AminoundecanoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCCCCCCCCCCC(=O)O

Technology Process of BOC-11-AMINOUNDECANOIC ACID

There total 7 articles about BOC-11-AMINOUNDECANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

11-aminoundecanoic acid (2432-99-7,25587-80-8,84029-94-7) + di-tert-butyl dicarbonate (24424-99-5) → 11-(tert-butoxycarbonylamino)undecanoic acid (10436-25-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1002/anie.202014813

Reference yield: 98.0%

→ 11-(tert-butoxycarbonylamino)undecanoic acid (10436-25-6)

Guidance literature:

Reference yield: 95.0%

11-[[(1,1-dimethylethoxy)carbonyl]amino]undecanoic acid triethylammonium salt → 11-(tert-butoxycarbonylamino)undecanoic acid (10436-25-6)

Guidance literature:

With 2-hydroxypropane-1,2,3-tricarboxylic acid; In water;

upstream raw materials:

11-aminoundecanoic acid

di-tert-butyl dicarbonate

2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

di-tert-butyl dicarbonate

Downstream raw materials:

2-(4-{11-[(tert-butoxycarbonyl)amino]undecanoyl}piperazin-1-yl)ethyl 4-amino-5-chloro-2-methoxybenzoate

(2S)-[2-(11-tert-butoxycarbonylaminoundecanoylamino)-acetylamino]-4-methyl-pentanoic acid 2,2-diphenyl-ethyl ester

2-[4-({11-[(tert-butoxycarbonyl)amino]undecanoyl}amino)piperidino]ethyl 4-amino-5-chloro-2-methoxybenzoate

[deamino-Cys⁽¹⁾,Leu⁽⁴⁾,Lys(11-aminoundecanoyl)⁽⁸⁾]vasopressin

Refernces

• 1、 Liu, Jianjia,Yan, Liang,Wang, Jie,Li, Tao,Zhao, Hanqing,Li, Li,Lincoln, Stephen F.,Prud'homme, Robert K.,Guo, Xuhong. "Reversible photo-responsive vesicle based on the complexation between an azobenzene containing molecule and α-cyclodextrin". . p. 32846 - 32852. Retrieved 2015.
• 2、 Leydet, Alain,Barragan, Véronique,Boyer, Bernard,Montéro, Jean Louis,Roque, Jean Pierre,Witvrouw, Myriam,Este, José,Snoeck, Robert,Andrei, Graciela,De Clercq, Erick. "Polyanion inhibitors of human immunodeficiency virus and other viruses. 5. Telomerized anionic surfactants derived from amino acids". . p. 342 - 349. Retrieved 1997.
• 3、 Bartoli, Giuseppe,Bosco, Marcella,Locatelli, Manuela,Marcantoni, Enrico,Massaccesi, Massimo,Melchiorre, Paolo,Sambri, Letizia. "A Lewis acid-mediated protocol for the protection of aryl amines as their Boc-derivatives". . p. 1794 - 1798. Retrieved 2004.
• 4、 Ni, Jingxuan,Guo, Mengqi,Cao, Yucheng,Lei, Lei,Liu, Kangli,Wang, Binghua,Lu, Fangfang,Zhai, Rong,Gao, Xiangwei,Yan, Chunhong,Wang, Hongbo,Bi, Yi. "Discovery, synthesis of novel fusidic acid derivatives possessed amino-terminal groups at the 3-hydroxyl position with anticancer activity". . p. 122 - 131. Retrieved 2019.
• 5、 Chakraborty, Debayan,Sarkar, Deblina,Ghosh, Anup Kumar,Das, Prasanta Kumar. "Lipase sensing by naphthalene diimide based fluorescent organic nanoparticles: a solvent induced manifestation of self-assembly". . p. 2170 - 2180. Retrieved 2021/03/14.