Tyr-Tyr-Tyr

Base Information

• Chemical Name: Tyr-Tyr-Tyr
• CAS No.: 7390-78-5
• Molecular Formula: C27H29 N3 O7
• Molecular Weight: 507.543
• DSSTox Substance ID: DTXSID00404802
• Mol file: 7390-78-5.mol

Synonyms:Tyr-Tyr-Tyr;2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acid;SCHEMBL10789173;DTXSID00404802

Chemical Property of Tyr-Tyr-Tyr

Chemical Property:

• Boiling Point: 940.6±65.0 °C(Predicted)
• PKA: 3.07±0.10(Predicted)
• PSA: 182.21000
• Density: 1.387±0.06 g/cm3(Predicted)
• LogP: 2.69490
• Storage Temp.: −20°C
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 11
• Exact Mass: 507.20055027
• Heavy Atom Count: 37
• Complexity: 742

Purity/Quality:

98%Min ^*data from raw suppliers

Tyr-Tyr-Tyr ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)O)N)O

Technology Process of Tyr-Tyr-Tyr

There total 7 articles about Tyr-Tyr-Tyr which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Tyr-OMe (1080-06-4) → (S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionic acid (1050-28-8) + L-tyrosyl-L-tyrosyl-L-tyrosine (7390-78-5) + cis-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione (10125-11-8)

Guidance literature:

With aminolysin-A; In water; dimethyl sulfoxide; at 50 ℃; for 6h; pH=8; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0ob00403k

Reference yield:

L-Tyr-NH2 (4985-46-0) → Tyr-Tyr-Tyr-NH2 (172612-18-9) + (S)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionic acid (1050-28-8) + L-tyrosyl-L-tyrosyl-L-tyrosine (7390-78-5) + cis-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione (10125-11-8)

Guidance literature:

With aminolysin-A; In water; dimethyl sulfoxide; at 50 ℃; for 6h; pH=8; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0ob00403k

Reference yield:

L-tyrosine benzyl ester (42406-77-9) → L-tyrosyl-L-tyrosyl-L-tyrosine (7390-78-5) + cis-3,6-bis(4-hydroxybenzyl)piperazine-2,5-dione (10125-11-8)

Guidance literature:

With aminolysin-A; In water; dimethyl sulfoxide; at 50 ℃; for 6h; pH=8; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1039/c0ob00403k

upstream raw materials:

N-benzyloxycarbonyl-L-tyrosyl-L-tyrosyl-L-tyrosine

O-acetyl-N-benzyloxycarbonyl-L-tyrosyl chloride

O-acetyl-N-benzyloxycarbonyl L-tyrosine

L-tyrosine benzyl ester

Refernces