2,5-Diaminoadipic acid 2HCl

Base Information

• Chemical Name: 2,5-Diaminoadipic acid 2HCl
• CAS No.: 52408-04-5
• Molecular Formula: C₆H₁₂N₂O₄*2ClH
• Molecular Weight: 249.094
• Hs Code.: 2922499990
• Mol file: 52408-04-5.mol

Synonyms:2,5-Diaminoadipicacid dihydrochloride;

Chemical Property of 2,5-Diaminoadipic acid 2HCl

Chemical Property:

• PSA: 126.64000
• LogP: 1.59500
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

2,5-Diaminoadipic acid dihydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Diaminoadipic acid 2HCl

There total 9 articles about 2,5-Diaminoadipic acid 2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3R,6S)-Hexahydro-pyridazine-3,6-dicarboxylic acid; hydrochloride → (2R,5S)-2,5-Diamino-hexanedioic acid; hydrochloride (213686-08-9,52408-04-5)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; for 9h; under 760 Torr;

DOI:10.1248/cpb.46.674

Reference yield:

(3S,6R)-1,2-Dibenzoyl-hexahydro-pyridazine-3,6-dicarboxylic acid dimethyl ester (170877-83-5) → (2R,5S)-2,5-Diamino-hexanedioic acid; hydrochloride (213686-08-9,52408-04-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / 6 N HCl, AcOH / 24 h / 100 °C

2: 100 percent / H₂, 2 N HCl / PtO₂ / 9 h / 760 Torr

With hydrogenchloride; hydrogen; acetic acid; platinum(IV) oxide;

DOI:10.1248/cpb.46.674

Reference yield:

diethyl 2,5-dibromoadipate (869-10-3) → (2S,5S)-2,5-Diamino-hexanedioic acid; hydrochloride (213686-08-9,52408-04-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 81 percent / dimethylformamide / 2 h / 90 °C

2: methylhydrazine / ethanol / 2 h / Heating

3: EtONa / ethanol / 1 h / Heating

4: 97 percent / 0.65 M HCl / Ambient temperature

5: 91 percent / DCC, pyridine, DMAP / CH₂Cl₂ / 64 h / Ambient temperature

7: 23 mg / 6N aq. HCl / 4 h / Heating

With pyridine; hydrogenchloride; dmap; sodium ethanolate; dicyclohexyl-carbodiimide; methylhydrazine; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(96)00504-6

upstream raw materials:

(2S,5S)-6-Oxo-5-phenylacetylamino-piperidine-2-carboxylic acid methyl ester

diethyl 2,5-dibromoadipate

diethyl 2,5-diphthalimidoadipate

2,5-diazabicyclo<2.2.2>octane-3,6-dione

Refernces

• 1、 Ducep,Heintzelmann,Jund,Lesur,Schleimer,Zimmermann. "Synthesis of (2S,5S)-5-fluoromethylornithine; a potent inhibitor of ornithine aminotransferase". . p. 327 - 335. Retrieved 2007/10/03.