Technology Process of methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate
There total 17 articles about methyl 2-[({2'-[1-benzyl-1H-tetrazol-5-yl]biphenyl-4-yl}methyl)amino]-3-aminobenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tin(II) chloride dihdyrate;
In
methanol;
for 2h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 5 h / 140 °C / Inert atmosphere
2: sodium methylate / methanol / 18 - 20 °C
3: phosphorus tribromide / tetrahydrofuran / -9 - 12 °C
4: potassium carbonate / acetonitrile / 9 h / Reflux; Inert atmosphere
5: hydrogenchloride / methanol / 20 °C / Cooling with ice
6: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
With
hydrogenchloride; tin(II) chloride dihdyrate; sodium methylate; phosphorus tribromide; potassium carbonate; triphenylphosphine;
dichloro(1,5-cyclooctadiene)ruthenium(II) polymer;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: triethylamine / tetrahydrofuran / 2 - 35 °C
2.1: phosphorus pentachloride / dichloromethane / -15 - 21 °C
2.2: 4.5 h / -8 - 20 °C
3.1: potassium carbonate; triphenylphosphine / dichloro(1,5-cyclooctadiene)ruthenium(II) polymer / 1-methyl-pyrrolidin-2-one / 5 h / 140 °C / Inert atmosphere
4.1: sodium methylate / methanol / 18 - 20 °C
5.1: phosphorus tribromide / tetrahydrofuran / -9 - 12 °C
6.1: potassium carbonate / acetonitrile / 9 h / Reflux; Inert atmosphere
7.1: hydrogenchloride / methanol / 20 °C / Cooling with ice
8.1: tin(II) chloride dihdyrate / methanol / 2 h / Reflux
With
hydrogenchloride; tin(II) chloride dihdyrate; phosphorus pentachloride; sodium methylate; phosphorus tribromide; potassium carbonate; triethylamine; triphenylphosphine;
dichloro(1,5-cyclooctadiene)ruthenium(II) polymer;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; acetonitrile;