2,3,5-Tri-O-benzyl-D-ribose

Base Information

• Chemical Name: 2,3,5-Tri-O-benzyl-D-ribose
• CAS No.: 54623-25-5
• Molecular Formula: C26H28O5
• Molecular Weight: 420.5
• Hs Code.: 2912499000
• Mol file: 54623-25-5.mol

Synonyms:2,3,5-tri-O-benzyl-d-ribose

Chemical Property of 2,3,5-Tri-O-benzyl-D-ribose

Chemical Property:

• Refractive Index: 1.582
• Boiling Point: 591.5 °C at 760 mmHg
• PKA: 13.28±0.20(Predicted)
• Flash Point: 197.7 °C
• PSA: 64.99000
• Density: 1.175g/cm³
• LogP: 3.93380
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Water Solubility.: Sparingly soluble in water.(0.26 g/L) (25°C),
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 13
• Exact Mass: 420.19367399
• Heavy Atom Count: 31
• Complexity: 466

Purity/Quality:

99% ^*data from raw suppliers

2,3,5-Tri-O-benzyl-D-ribose 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COCC(C(C(C=O)OCC2=CC=CC=C2)OCC3=CC=CC=C3)O
• Isomeric SMILES: C1=CC=C(C=C1)COC[C@H]([C@H]([C@H](C=O)OCC2=CC=CC=C2)OCC3=CC=CC=C3)O
• Uses: It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Technology Process of 2,3,5-Tri-O-benzyl-D-ribose

There total 2 articles about 2,3,5-Tri-O-benzyl-D-ribose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ 2,3,5-tri-O-benzyl-D-ribose (54623-25-5)

Guidance literature:

Reference yield:

methyl 2,3,5-tri-O-benzyl-D-ribofuranoside (64363-77-5) → 2,3,5-tri-O-benzyl-D-ribose (54623-25-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Heating;

DOI:10.1002/cber.19771100704

Reference yield:

2,3,5-tri-O-benzyl-D-ribose (54623-25-5) → 1-hydrazino-2,3,5-tri-O-benzyl-D-ribose

Guidance literature:

With hydrazine hydrate; In methanol;

upstream raw materials:

methyl 2,3,5-tri-O-benzyl-D-ribofuranoside

Downstream raw materials:

2,3,5-Tri-O-benzyl-D-ribosehydrazon

2,3,5-tri-O-benzyl-1-deoxy-D-ribofuranose

Refernces

• 1、 Schmidt,Karg,Guilliard. "Glycosylhydrazines. 2. Synthesis of pyrazole nucleosides via ribosylhydrazines". . p. 2433 - 2444. Retrieved 2007/10/05.