(3S)-(-)-3-(ETHYLAMINO)PYRROLIDINE

Base Information

• Chemical Name: (3S)-(-)-3-(ETHYLAMINO)PYRROLIDINE
• CAS No.: 381670-31-1
• Molecular Formula: C₆H₁₄N₂
• Molecular Weight: 114.191
• Hs Code.: 2933990090
• Mol file: 381670-31-1.mol

Synonyms:(3S)-3-(Ethylamino)pyrrolidine;(3S)-N-Ethyl-3-pyrrolidinamine

Chemical Property of (3S)-(-)-3-(ETHYLAMINO)PYRROLIDINE

Chemical Property:

• Vapor Pressure: 1.68mmHg at 25°C
• Refractive Index: -15 ° (C=10, EtOH)
• Boiling Point: 176°C
• PKA: 10.59±0.10(Predicted)
• Flash Point: 54℃
• PSA: 24.06000
• Density: 0,92 g/cm3
• LogP: 0.67750
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(3S)-(-)-3-(Ethylamino)pyrrolidine ^*data from reagent suppliers

Safty Information:

• Statements: 10
• Safety Statements: 16

MSDS Files:

Useful:

Technology Process of (3S)-(-)-3-(ETHYLAMINO)PYRROLIDINE

There total 2 articles about (3S)-(-)-3-(ETHYLAMINO)PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

(R)-1-benzyl-N-ethylpyrrolidine-3-amine (115445-21-1,169750-99-6,376591-05-8) → (R)-3-ethylaminopyrrolidine (381670-30-0,381670-31-1)

Guidance literature:

With ammonium formate; palladium hydroxide on carbon; In methanol; for 2.5h; Heating / reflux;

Reference yield:

1-Benzyl-3-aminopyrrolidine (18471-40-4,60652-45-1,114715-38-7,114715-39-8) → 3-(ethylamino)pyrrolidine (111390-22-8,381670-31-1)

Guidance literature:

With sodium hydroxide; acetic anhydride; palladium on charcoal; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid;

Reference yield:

(3S)-(-)-3-(ethylamino)pyrrolidine (381670-31-1) + 5-(4-chloro-6-propylpyrimidin-2-ylamino)-2-methylbenzonitrile (1394321-72-2) → (S)-5-{4-[3-(ethylamino)pyrrolidin-1-yl]-6-propylpyrimidin-2-ylamino}-2-methylbenzonitrile hydrochloride

Guidance literature:

In isopropyl alcohol; Reflux;

upstream raw materials:

1-Benzyl-3-aminopyrrolidine

(R)-1-benzyl-N-ethylpyrrolidine-3-amine

Downstream raw materials:

C₂₁H₂₁F₄N₃O₂

(+/-)-1-(1-(3,4-dichlorobenzyl)pyrrolidin-3-yl)-1-ethyl-3-(4-fluoro-3-(trifluoromethyl)phenyl)urea

Refernces

• 1、 -. "Naphthyridine antibacterial agents". . . Retrieved 2008/06/13.
• 2、 -. "Antibacterial agents". . . Retrieved 2008/06/13.