2-BROMOBENZYL CHLORIDE

Base Information

• Chemical Name: 2-BROMOBENZYL CHLORIDE
• CAS No.: 578-51-8
• Molecular Formula: C7H6BrCl
• Molecular Weight: 205.482
• Mol file: 578-51-8.mol

Synonyms:1-Bromo-2-(chloromethyl)benzene;Toluene,o-bromo-a-chloro- (6CI,7CI,8CI);o-Bromobenzyl chloride;

Chemical Property of 2-BROMOBENZYL CHLORIDE

Chemical Property:

• Appearance/Colour: Clear colorless to pale yellow liquid
• Vapor Pressure: 0.0596mmHg at 25°C
• Refractive Index: 1.586
• Boiling Point: 240.18 °C at 760 mmHg
• Flash Point: 109.378 °C
• PSA: 0.00000
• Density: 1.541 g/cm³
• LogP: 3.18790
• Water Solubility.: Not miscible or difficult to mix with water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-BromobenzylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromobenzyl chloride is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Technology Process of 2-BROMOBENZYL CHLORIDE

There total 6 articles about 2-BROMOBENZYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

o-bromobenzyl alcohol (18982-54-2) → 2-bromobenzylchloride (578-51-8)

Guidance literature:

With thionyl chloride; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201203435

Reference yield:

sulfuryl dichloride (7791-25-5) + 2-methylphenyl bromide (95-46-5) + dibenzoyl peroxide (94-36-0) → 2-methylchlorobenzene (95-49-8) + 1-chloro-2-(chloromethyl)benzene (611-19-8) + 2-bromobenzylchloride (578-51-8) + 1-Bromo-2-bromomethyl-benzene (3433-80-5)

Guidance literature:

at 110 ℃;

DOI:10.1021/ja01150a509

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + bromobenzene (108-86-1,52753-63-6) → 2-bromobenzylchloride (578-51-8) + p-bromobenzyl chloride (589-17-3)

Guidance literature:

With hydrogenchloride; tin(IV) chloride; die Trennung der Isomeren erfolgt durch Abkuehlen auf -15grad;

upstream raw materials:

formaldehyd

bromobenzene

2-methylphenyl bromide

o-bromobenzyl alcohol

Downstream raw materials:

1-bromo-2-((p-tolyloxy)methyl)benzene

2-(2-bromo-benzyl)-4-methyl-phenol

(3-bromo-benzyl)-p-tolyl ether

2,6-dibromo-4-(2-bromo-benzyl)-phenol

Refernces

• 1、 Zheng, Dagui,Mao, Liu-Liang,Zhu, Xian-Hong,Zhou, An-Xi. "NMP-mediated chlorination of aliphatic alcohols with aryl sulfonyl chloride for the synthesis of alkyl chlorides". supporting information. p. 2793 - 2800. Retrieved 2018/11/06.
• 2、 Bedford, Robin B.,Gallagher, Timothy,Pye, Dominic R.,Savage, William. "Towards iron-catalysed suzuki biaryl cross-coupling: Unusual reactivity of 2-halobenzyl halides". . p. 1761 - 1765. Retrieved 2015/06/16.