BOC-D-ALA-OME

Base Information

• Chemical Name: BOC-D-ALA-OME
• CAS No.: 91103-47-8
• Molecular Formula: C9H17NO4
• Molecular Weight: 203.238
• Hs Code.: 2924297099
• Mol file: 91103-47-8.mol

Synonyms:N-(tert-Butoxycarbonyl)-D-alaninemethyl ester;alanine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester;Boc-D-Alanine methyl ester;

Chemical Property of BOC-D-ALA-OME

Chemical Property:

• Vapor Pressure: 0.00443mmHg at 25°C
• Melting Point: 34-37 °C(lit.)
• Refractive Index: 1.438
• Boiling Point: 277.8 °C at 760 mmHg
• PKA: 11.21±0.46(Predicted)
• Flash Point: 121.8 °C
• PSA: 64.63000
• Density: 1.051 g/cm³
• LogP: 1.46350
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Boc-D-Ala-OMe ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-D-ALA-OME

There total 1 articles about BOC-D-ALA-OME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-{[(tert-butoxy)carbonyl]amino}propanoate (112392-66-2) → L-N-Boc-Ala (15761-38-3) + N-(tert-butoxycarbonyl)-D-alanine methyl ester (91103-47-8)

Guidance literature:

With lyophilized cells of Bacillus amyloliquefaciens WZZ₀₀₂; In aq. phosphate buffer; at 35 ℃; for 10h; pH=8; Solvent; Reagent/catalyst; pH-value; Temperature; Time; Concentration; enantioselective reaction; Kinetics; Enzymatic reaction;

DOI:10.1016/j.catcom.2014.10.017

Reference yield: 100.0%

methylmagnesium bromide (75-16-1) + N-(tert-butoxycarbonyl)-D-alanine methyl ester (91103-47-8) → ((R)-2-hydroxy-1,2-dimethyl-propyl)-carbamic acid tert-butyl ester (186466-64-8)

Guidance literature:

methylmagnesium bromide; N-(tert-butoxycarbonyl)-D-alanine methyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

With water; In tetrahydrofuran; Cooling with ice;

Reference yield: 99.0%

N-(tert-butoxycarbonyl)-D-alanine methyl ester (91103-47-8) → ((R)-2-hydroxy-1,2-dimethyl-propyl)-carbamic acid tert-butyl ester (186466-64-8)

Guidance literature:

With methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 3h;

upstream raw materials:

methyl 2-{[(tert-butoxy)carbonyl]amino}propanoate

Downstream raw materials:

((R)-3-tert-Butoxycarbonylamino-2-oxo-butyl)-phosphonic acid benzyl ester methyl ester

(R)-2-tertbutoxycarbonylamino-1-propanol

(2R)-2-N-t-butoxycarbonyl-aminopropanal

((R)-2-hydroxy-1,2-dimethyl-propyl)-carbamic acid tert-butyl ester

Refernces