Multi-step reaction with 6 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1.5 h / -78 - 70 °C / Inert atmosphere
1.2: 1.5 h / -78 - -20 °C / Inert atmosphere
2.1: Methanesulfonic anhydride; triethylamine / dichloromethane / 0.5 h / 5 °C / Inert atmosphere
2.2: 40 h / 5 - 20 °C / Inert atmosphere
3.1: sodium hydroxide / tetrahydrofuran; water; methanol / 0.5 h / 20 °C / Inert atmosphere
4.1: diethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 10 h / 80 °C / Inert atmosphere
5.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane; water / 0.5 h / 80 - 110 °C / Inert atmosphere
6.1: Chiralpak AD-H / ethanol; n-heptane / Resolution of racemate
With
potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; diethylamine; triethylamine; sodium hydroxide; lithium diisopropyl amide; Methanesulfonic anhydride;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide;