2-Methyl-3-amino-4-acetylanisole

Base Information

• Chemical Name: 2-Methyl-3-amino-4-acetylanisole
• CAS No.: 912347-94-5
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• Hs Code.: 2922509090
• Mol file: 912347-94-5.mol

Synonyms:(2-Amino-3-methyl-4-methoxyphenyl)acetone;

Chemical Property of 2-Methyl-3-amino-4-acetylanisole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 107 °C
• Refractive Index: 1.549
• Boiling Point: 336.02 °C at 760 mmHg
• PKA: 1.74±0.10(Predicted)
• Flash Point: 171.127 °C
• PSA: 52.32000
• Density: 1.096 g/cm³
• LogP: 2.36960
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-Amino-4-methoxy-3-methylphenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methyl-3-amino-4-acetylanisole

There total 4 articles about 2-Methyl-3-amino-4-acetylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

acetonitrile (75-05-8,26809-02-9) + 2-methyl-3-methoxyaniline (19500-02-8) → 1-(2-amino-4-methoxy-3-methyl-phenyl)ethanone (912347-94-5)

Guidance literature:

2-methyl-3-methoxyaniline; With boron trichloride; In dichloromethane; para-xylene; at 0 ℃; for 0.5h; Inert atmosphere;

acetonitrile; With aluminum (III) chloride; In dichloromethane; para-xylene; at 0 - 70 ℃; Inert atmosphere;

With water; In para-xylene; at 70 ℃; for 1h;

Reference yield: 68.0%

2-amino-4-methoxy-3-methylbenzonitrile (923274-68-4) + methylmagnesium bromide (75-16-1) → 1-(2-amino-4-methoxy-3-methyl-phenyl)ethanone (912347-94-5)

Guidance literature:

2-amino-4-methoxy-3-methylbenzonitrile; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 55 ℃; for 4h;

With hydrogenchloride; water; In tetrahydrofuran; diethyl ether; at 0 ℃; Product distribution / selectivity;

Reference yield: 40.0%

acetonitrile (75-05-8,26809-02-9) → 1-(2-amino-4-methoxy-3-methyl-phenyl)ethanone (912347-94-5)

Guidance literature:

2-methyl-3-methoxyaniline; With boron trichloride; In dichloromethane; xylene; at 0 - 10 ℃; for 0.5h;

acetonitrile; In dichloromethane; xylene; at 0 - 5 ℃; for 0.5h;

With aluminum (III) chloride; sodium hydroxide; water; more than 3 stages; Product distribution / selectivity;

upstream raw materials:

2-amino-4-methoxy-3-methylbenzonitrile

methylmagnesium bromide

acetonitrile

2-methyl-3-methoxyaniline

Downstream raw materials:

N-(6-acetyl-2-methyl-3-methoxyphenyl)-4-isopropylthiazole-2-carboxamide

4-trifluoromethyl-1,3-thiazole-2-carboxylic acid (6-acetyl-3-methoxy-2-methyl-phenyl)amide

N-(6-acetyl-3-methoxy-2-methylphenyl)-4-cyclopropylthiazole-2-carboxamide

8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]-7-(methyloxy)-4-quinolinol

Refernces

• 1、 -. "COMPOUNDS". Page/Page column 20. . Retrieved 2010/08/08.
• 2、 -. "HCV INHIBITING MACROCYCLIC PHOSPHONATES AND AMIDOPHOSPHATES". Page/Page column 82-83. . Retrieved 2008/12/08.