Triformylmethane

Base Information

• Chemical Name: Triformylmethane
• CAS No.: 18655-47-5
• Molecular Formula: C4H4 O3
• Molecular Weight: 100.074
• Hs Code.: 2912190090
• Mol file: 18655-47-5.mol

Synonyms:3-Formylmalondialdehyde;Formylmalonaldehyde; Formylmalondialdehyde; Triformylmethane

Chemical Property of Triformylmethane

Chemical Property:

• Vapor Pressure: 9.62mmHg at 25°C
• Melting Point: 102.5-103.5 °C (sublm)
• Boiling Point: 131 ºC
• PKA: 1.54±0.59(Predicted)
• Flash Point: 32 ºC
• PSA: 51.21000
• Density: 1.151
• LogP: -0.80070
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methanetricarbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Triformylmethane

There total 4 articles about Triformylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate (2009-81-6) → triformylmethane (18655-47-5)

Guidance literature:

With sodium hydroxide; In methanol;

DOI:10.1002/anie.201803647

Reference yield: 55.0%

bromoacetic acid (79-08-3) → triformylmethane (18655-47-5)

Guidance literature:

bromoacetic acid; With trichlorophosphate; In N,N-dimethyl-formamide; at 15 - 100 ℃; for 10h;

With bromine; sodium bromide; In water; at 10 ℃; for 1h; Cooling with ice;

Reference yield: 45.0%

bromoacetic acid (79-08-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → triformylmethane (18655-47-5)

Guidance literature:

With trichlorophosphate; at 70 ℃; for 24h;

DOI:10.1002/ejoc.200400013

upstream raw materials:

bromoacetic acid

N,N-dimethyl-formamide

3-dimethylaminoacrolein

2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate

Downstream raw materials:

1-methylpyrazole-4-carbaldehyde

2-[(1-Methyl-2-oxo-1,2-dihydro-pyrimidin-4-ylamino)-methylene]-malonaldehyde

benzene-1,3,5-trialdehyde

C₃₀H₃₅N₂O⁽¹⁺⁾*Cl^(1-)

Refernces

• 1、 Zoppellaro, Giorgio,Geies, Ahmed,Enkelmann, Volker,Baumgarten, Martin. "2,6-Bis(pyrazolyl)pyridine functionalised with two nitronylnitroxide and iminonitroxide radicals". . p. 2367 - 2374. Retrieved 2004.
• 2、 -. "Preparation method of anagliptin intermediate". Paragraph 0017; 0033-0048. . Retrieved 2019/07/29.
• 3、 -. "NOVEL HETEROCYCLIC COMPOUNDS AS INHIBITORS OF VANIN-1 ENZYME". Page/Page column 103. . Retrieved 2016/12/22.