H-PHE-OBZL P-TOSYLATE

Base Information

• Chemical Name: H-PHE-OBZL P-TOSYLATE
• CAS No.: 88224-00-4
• Molecular Formula: C12H15NO2^.C7H8O3S
• Molecular Weight: 377.461
• Hs Code.: 2923900090
• Mol file: 88224-00-4.mol

Synonyms:L-Phenylalanine allyl ester tosylate;(2S)-1-oxo-3-phenyl-1-(prop-2-en-1-yloxy)propan-2-aminium 4-methylbenzenesulfonate;L-Phenylalanine allyl ester p-toluenesulfonate salt;

Chemical Property of H-PHE-OBZL P-TOSYLATE

Chemical Property:

• Vapor Pressure: 0.000667mmHg at 25°C
• Melting Point: 155-158 °C
• Boiling Point: 308.8 °C at 760 mmHg
• Flash Point: 162.6 °C
• PSA: 115.07000
• LogP: 4.30840
• Storage Temp.: −20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Phenylalanine allyl ester 4-toluenesulfonate salt ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PHE-OBZL P-TOSYLATE

There total 1 articles about H-PHE-OBZL P-TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + toluene-4-sulfonic acid (104-15-4) + allyl alcohol (107-18-6) → L-phenylalanine allyl ester p-toluenesulfonic acid salt (88224-00-4,367512-59-2)

Guidance literature:

In benzene; Heating;

Reference yield: 87.0%

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) + L-phenylalanine allyl ester p-toluenesulfonic acid salt (88224-00-4,367512-59-2) → N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-allylester (88224-12-8)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; for 12h; Ambient temperature;

Reference yield: 82.0%

N-benzyloxycarbonyl-L-cysteine (50299-23-5) + L-phenylalanine allyl ester p-toluenesulfonic acid salt (88224-00-4,367512-59-2) → N-benzyloxycarbonyl-L-cysteinyl-L-phenylalanine allyl ester

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; triethylamine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1080/07328303.2019.1567755

upstream raw materials:

L-phenylalanine

toluene-4-sulfonic acid

allyl alcohol

Downstream raw materials:

N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-allylester

N-Benzyloxycarbonyl-L-valyl-L-phenylalanin-allylester

Phe-Phe

L-phenylalanyl-L-phenylalanine methyl ester

Refernces