H-D-PHE-OBZL P-TOSYLATE

Base Information

• Chemical Name: H-D-PHE-OBZL P-TOSYLATE
• CAS No.: 28607-46-7
• Molecular Formula: C23H25NO5S
• Molecular Weight: 427.51
• Hs Code.: 2923900090
• Mol file: 28607-46-7.mol

Synonyms:D-Phenylalanine benzyl ester tosylate;(2R)-1-(benzyloxy)-1-oxo-3-phenylpropan-2-aminium 4-methylbenzenesulfonate;H-D-Phe-OBzl.HCl;Benzyl D-phenylalaninate 4-methylbenzenesulfonate (1:1);D-Phenylalanine Benzyl Ester p-Toluenesulfonate;

Chemical Property of H-D-PHE-OBZL P-TOSYLATE

Chemical Property:

• Vapor Pressure: 4.62E-06mmHg at 25°C
• Melting Point: 169 °C
• Refractive Index: 6 ° (C=2, MeOH)
• Boiling Point: 382.8 °C at 760 mmHg
• Flash Point: 220.4 °C
• PSA: 115.07000
• LogP: 5.32260
• Storage Temp.: Store at RT.
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

D-Phenylalanine benzyl ester 4-toluenesulfonate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-PHE-OBZL P-TOSYLATE

There total 1 articles about H-D-PHE-OBZL P-TOSYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

D-(R)-phenylalanine (673-06-3,25191-15-5,658-69-5,67675-33-6) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → (R)-phenylalanine benzyl ester p-toluenosulfonate (28607-46-7)

Guidance literature:

In benzene; Heating;

DOI:10.1021/jm970475+

Reference yield: 100.0%

(R)-phenylalanine benzyl ester p-toluenosulfonate (28607-46-7) + oxaziridine-2,3,3-tricarboxylic acid 2-tert-butyl ester 3,3-diethyl ester (462100-44-3) → H-(N-NHBoc)D-Phe-OBn

Guidance literature:

With sodium hydrogencarbonate; In tetrahydrofuran; water;

Reference yield: 88.1%

Boc-D-Trp(For)-OH (64905-10-8) + (R)-phenylalanine benzyl ester p-toluenosulfonate (28607-46-7) → Boc-D-Trp(CHO)-D-Phe-OBzl (137380-87-1)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide; for 3h;

DOI:10.1021/jm00089a011

upstream raw materials:

D-(R)-phenylalanine

toluene-4-sulfonic acid

benzyl alcohol

Downstream raw materials:

Boc-Pro-D-Phe-OBzl

Boc-D-Trp(CHO)-D-Phe-OBzl

(R)-2-(Biphenyl-4-sulfonylamino)-3-phenyl-propionic acid benzyl ester

Fmoc-Ala-Pro-D-Phe-OBn

Refernces

• 1、 Deal, Kim A.,Welch, Michael J.. "Effect of stereochemistry on the clearance mechanism of 111in(III)- LABELED D- or L-benzyldiethylenetriaminepentaacetic acid". . p. 3986 - 3989. Retrieved 2007/10/03.