C₁₂H₁₆Cl₂O

Base Information

• Chemical Name: C₁₂H₁₆Cl₂O
• CAS No.: 1351663-13-2
• Molecular Formula: C₁₂H₁₆Cl₂O
• Molecular Weight: 247.164
• Mol file: 1351663-13-2.mol

Synonyms:C₁₂H₁₆Cl₂O

Chemical Property of C₁₂H₁₆Cl₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₂H₁₆Cl₂O

There total 4 articles about C₁₂H₁₆Cl₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

tetrachloromethane (56-23-5) + C11H16O2 (1351663-02-9) → C12H16Cl2O (1351663-13-2)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; for 12h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2011.09.103

Reference yield:

1-(1-nitroethyl)cyclohexene (90087-64-2) → C12H16Cl2O (1351663-13-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / Inert atmosphere; Reflux

2: water; acetic acid / Inert atmosphere

3: triphenylphosphine / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

With water; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; In tetrahydrofuran; acetonitrile; 1: Michael addition / 3: Wittig type condensation;

DOI:10.1016/j.tet.2011.09.103

Reference yield:

4-Cyclohex-1-enyl-4-nitro-pentanoic acid methyl ester (107752-19-2) → C12H16Cl2O (1351663-13-2)

Guidance literature:

Multi-step reaction with 2 steps

1: water; acetic acid / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran / 12 h / Inert atmosphere; Reflux

With water; acetic acid; triphenylphosphine; In tetrahydrofuran; 2: Wittig type condensation;

DOI:10.1016/j.tet.2011.09.103

upstream raw materials:

tetrachloromethane

C₁₁H₁₆O₂

1-(1-nitroethyl)cyclohexene

cyclohexanone

Refernces