4-bromo-5-chloro-2-nitrophenylamine

Base Information

• Chemical Name: 4-bromo-5-chloro-2-nitrophenylamine
• CAS No.: 827-33-8
• Molecular Formula: C6H4BrClN2O2
• Molecular Weight: 251.467
• Hs Code.: 2921420090
• Mol file: 827-33-8.mol

Synonyms:4-Bromo-5-chloro-2-nitroaniline;Aniline,4-bromo-5-chloro-2-nitro- (8CI);2-Nitro-4-bromo-5-chloroaniline;3-Chloro-4-bromo-6-nitroaniline;4-Bromo-5-chloro-2-nitroaniline;

Chemical Property of 4-bromo-5-chloro-2-nitrophenylamine

Chemical Property:

• Boiling Point: 350.5 °C at 760 mmHg
• PKA: -2.29±0.25(Predicted)
• Flash Point: 165.8 °C
• PSA: 71.84000
• Density: 1.909 g/cm³
• LogP: 3.69730
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

4-Bromo-5-chloro-2-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-bromo-5-chloro-2-nitrophenylamine

There total 6 articles about 4-bromo-5-chloro-2-nitrophenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

5-chloro-2-nitroaniline (1635-61-6) → 2-nitro-4-bromo-5-chloro-aniline (827-33-8)

Guidance literature:

With N-Bromosuccinimide; acetic acid; at 30 ℃; for 1h;

Reference yield: 93.0%

N-(4-bromo-5-chloro-2-nitrophenyl)acetamide (716-66-5) → 2-nitro-4-bromo-5-chloro-aniline (827-33-8)

Guidance literature:

With sulfuric acid; In water; for 2.5h; Heating;

DOI:10.1002/hlca.200390102

Reference yield:

N-(4-bromo-5-chloro-2-nitro-phenyl)-2,2,2-trifluoro-acetamide (956282-97-6) → 2-nitro-4-bromo-5-chloro-aniline (827-33-8)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 10h;

upstream raw materials:

N-(4-bromo-3-chlorophenyl)acetamide

N-(4-bromo-5-chloro-2-nitrophenyl)acetamide

N-(4-bromo-5-chloro-2-nitro-phenyl)-2,2,2-trifluoro-acetamide

4-bromo-3-chloroaniline

Downstream raw materials:

N-(4-bromo-5-chloro-2-nitrophenyl)acetamide

5-bromo-6-chloro-1H-benzo[d]imidazol-2(3H)-one

4-(6-chlorobenzo[c][1,2,5]oxadiazol-5-yl)aniline

C₁₉H₁₀ClF₂N₃O₂

Refernces

• 1、 -. "HETEROARYL RHEB INHIBITORS AND USES THEREOF". Paragraph 00669. . Retrieved 2018/11/10.
• 2、 -. "HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES". Paragraph 1021. . Retrieved 2016/08/03.