5-bromo-3-methylpicolinonitrile

Base Information

• Chemical Name: 5-bromo-3-methylpicolinonitrile
• CAS No.: 156072-86-5
• Molecular Formula: C7H5BrN2
• Molecular Weight: 197.032
• Hs Code.: 2933399090
• Mol file: 156072-86-5.mol

Synonyms:5-bromo-3-methyl-2-pyridinecarbonitrile;5-bromo-3-methyl-2-cyanopyridine;5-bromo-3-methylpicolinenitrile;5-bromo-3-methylpicolinonitrile;5-Bromo-2-cyano-3-methylpyridine;5-bromo-2-cyano-3-picoline;查看更多英文别名收起

Chemical Property of 5-bromo-3-methylpicolinonitrile

Chemical Property:

• Boiling Point: 283.6 °C at 760 mmHg
• PKA: -2.38±0.20(Predicted)
• Flash Point: 125.3 °C
• PSA: 36.68000
• Density: 1.61 g/cm³
• LogP: 2.02418
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

5-bromo-3-methylpyridine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-bromo-3-methylpicolinonitrile

There total 7 articles about 5-bromo-3-methylpicolinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5-amino-3-methylpyridine-2-carbonitrile (252056-70-5) → 5-bromo-3-methylpyridine-2-carbonitrile (156072-86-5)

Guidance literature:

5-amino-3-methylpyridine-2-carbonitrile; With hydrogen bromide; sodium nitrite; In water; at 0 ℃; for 1h;

With copper; for 0.5h; Heating;

DOI:10.1016/S0968-0896(99)00103-0

Reference yield: 74.0%

2,5-dibromo-3-methylpyridine (3430-18-0,141315-43-7) + copper(l) cyanide → 5-bromo-3-methylpyridine-2-carbonitrile (156072-86-5)

Guidance literature:

In N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1021/jm201512x

Reference yield: 57.6%

2,5-dibromo-3-methylpyridine (3430-18-0,141315-43-7) + copper(I) cyanide (544-92-3) → 5-bromo-3-methylpyridine-2-carbonitrile (156072-86-5)

Guidance literature:

In N,N-dimethyl-formamide; at 120 ℃; for 12h;

upstream raw materials:

5-amino-3-methylpyridine-2-carbonitrile

2-cyano-3-methylpyridine

3-methyl-5-nitropyridine-2-carbonitrile

2,5-dibromo-3-methylpyridine

Downstream raw materials:

6-[(1S)-2-amino-1-(3-fluorobenzyl)ethyl]-3-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5,6-dihydro-7H-pyrrolo[3,4-b]pyridin-7-one

2-{3-(3-fluorophenyl)-2-[3-(1-methyl-1H-pyrazol-5-yl)-7-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]propyl}-1H-isoindole-1,3(2H)-dione

2-{3-(3-fluorophenyl)-2-[3-(1-methyl-1H-pyrazol-5-yl)-7-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]propyl}-1H-isoindole-1,3(2H)-dione

3-bromo-8-chloro-[1,7]naphthyridine

Refernces

• 1、 -. "INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL". Paragraph 0160. . Retrieved 2017/07/31.
• 2、 -. "HETEROCYCLIC COMPOUND". Paragraph 0694. . Retrieved 2016/09/26.