Cyclopentanecarbothioamide

Base Information

• Chemical Name: Cyclopentanecarbothioamide
• CAS No.: 42202-73-3
• Molecular Formula: C6H11NS
• Molecular Weight: 129.226
• Hs Code.: 2930909090
• Mol file: 42202-73-3.mol

Synonyms:Cyclopentanethiocarboxamide;

Chemical Property of Cyclopentanecarbothioamide

Chemical Property:

• Vapor Pressure: 0.127mmHg at 25°C
• Refractive Index: 1.583
• Boiling Point: 218.245 °C at 760 mmHg
• PKA: 13.12±0.20(Predicted)
• Flash Point: 85.792 °C
• PSA: 58.11000
• Density: 1.124 g/cm³
• LogP: 2.16300

Purity/Quality:

98%min ^*data from raw suppliers

Cyclopentanecarbothioamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopentanecarbothioamide

There total 3 articles about Cyclopentanecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

cyclopentylamide (3217-94-5) → cyclopentanecarbothioamide (42202-73-3)

Guidance literature:

With Lawessons reagent; In tetrahydrofuran; toluene; at 70 ℃;

Reference yield:

cyclopentanecarboxylic acid (3400-45-1) → cyclopentanecarbothioamide (42202-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / ethyl acetate / 2 h / 20 °C

1.2: 2 h / 45 °C

2.1: Lawessons reagent / toluene / 15 h / 20 °C

With Lawessons reagent; 1,1'-carbonyldiimidazole; In ethyl acetate; toluene;

Reference yield:

Cyclopentanecarboxylic acid chloride (4524-93-0) → cyclopentanecarbothioamide (42202-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / tetrahydrofuran / 0.17 h

2: Lawessons reagent / tetrahydrofuran; toluene / 70 °C

With Lawessons reagent; ammonia; In tetrahydrofuran; toluene;

upstream raw materials:

cyclopentylamide

cyclopentanecarboxylic acid

Cyclopentanecarboxylic acid chloride

Downstream raw materials:

methyl 2-cyclopentyl-4-(4-phenoxyphenyl)thiazole-5-carboxylate

Refernces

• 1、 -. "HETEROCYCLE-SUBSTITUED TETRACYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES". Page/Page column 85. . Retrieved 2014/08/06.
• 2、 -. "THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES". Page/Page column 51-52. . Retrieved 2008/06/13.