3,3-Diphenylalanine Hydrochloride

Base Information

• Chemical Name: 3,3-Diphenylalanine Hydrochloride
• CAS No.: 119273-60-8
• Molecular Formula: C15H16ClNO2
• Molecular Weight: 277.75
• Mol file: 119273-60-8.mol

Synonyms:DL-Phenylalanine,b-phenyl-, hydrochloride;Phenylalanine, b-phenyl-,hydrochloride (9CI);2-Amino-3,3-diphenylpropanoic acid hydrochloride;DL-3,3-Diphenylalanine hydrochloride;b-phenylphenylalanine hydrochloride;

Chemical Property of 3,3-Diphenylalanine Hydrochloride

Chemical Property:

• Melting Point: 180℃
• Boiling Point: 417.3 °C at 760 mmHg
• Flash Point: 206.2 °C
• PSA: 126.64000
• LogP: 3.46500

Purity/Quality:

99% ^*data from raw suppliers

Phenylalanine,?-phenyl-,hydrochloride(1:1) 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,3-Diphenylalanine Hydrochloride

There total 9 articles about 3,3-Diphenylalanine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl N-benzoyl-β-phenylphenylalaninate (305819-43-6) → 2-amino-3,3-diphenylpropanoic acid hydrochloride (119273-60-8)

Guidance literature:

With hydrogenchloride; acetic acid; In water; for 24h; Heating;

DOI:10.1016/j.tetasy.2006.08.007

Reference yield: 84.0%

2-acetylamino-3,3-diphenyl-propionic acid (149597-86-4) → 2-amino-3,3-diphenylpropanoic acid hydrochloride (119273-60-8)

Guidance literature:

With hydrogenchloride; In tert-butyl alcohol; under reflux;

DOI:10.7164/antibiotics.50.283

Reference yield: 82.0%

ethyl acetamido(diphenylmethyl)cyanoacetate (143646-43-9) → 2-amino-3,3-diphenylpropanoic acid hydrochloride (119273-60-8)

Guidance literature:

With hydrogenchloride; for 30h; Heating;

DOI:10.1021/jm00096a010

upstream raw materials:

ethyl acetamido(diphenylmethyl)cyanoacetate

2-acetylamino-3,3-diphenyl-propionic acid

diphenylchloromethane

glycine

Downstream raw materials:

2-Benzyloxycarbonylamino-3,3-diphenyl-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester

(S)-1-(2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid

(S)-1-((R)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

(S)-1-((S)-2-Benzyloxycarbonylamino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester

Refernces

• 1、 Royo, Soledad,Jimenez, Ana I.,Cativiela, Carlos. "Synthesis of enantiomerically pure β,β-diphenylalanine (Dip) and fluorenylglycine (Flg)". . p. 2393 - 2400. Retrieved 2007/10/03.
• 2、 Eid, Clark N.,Halligan, Noreen G.,Nicas, Thalia I.,Mullen, Deborah L.,Butler, Thomas F.,Loncharich, Richard J.,Paschal, Jonathan W.,Schofield, Christopher J.,Westwood, Nicholas J.,Cheng, Leifeng. "Tripeptide LY301621 and its diastereomers as methicillin potentiators against methicillin resistant Staphylococcus aureus". . p. 283 - 285. Retrieved 2007/10/03.