1-phenyl-1H-indazole-3-amino

Base Information

• Chemical Name: 1-phenyl-1H-indazole-3-amino
• CAS No.: 38079-40-2
• Molecular Formula: C₁₃H₁₁N₃
• Molecular Weight: 209.25
• Mol file: 38079-40-2.mol

Synonyms:1-phenyl-1H-indazole-3-amino

Chemical Property of 1-phenyl-1H-indazole-3-amino

Chemical Property:

Purity/Quality:

99%,98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-1H-indazole-3-amino

There total 12 articles about 1-phenyl-1H-indazole-3-amino which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Chlorobenzonitrile (873-32-5) + phenylhydrazine (100-63-0) → 1-phenyl-1H-indazole-3-amino (38079-40-2)

Guidance literature:

With potassium tert-butylate; at 20 - 130 ℃; for 1h; Reagent/catalyst; Temperature; Time; Glovebox; Sealed tube;

Reference yield: 90.0%

bromobenzene (108-86-1,52753-63-6) + 3-aminoindazole (874-05-5) → 1-phenyl-1H-indazole-3-amino (38079-40-2)

Guidance literature:

With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; In 1,4-dioxane; at 110 ℃; for 18h;

DOI:10.1002/ejoc.202101245

Reference yield: 87.0%

3-aminoindazole (874-05-5) + phenylboronic acid (98-80-6) → 1-phenyl-1H-indazole-3-amino (38079-40-2)

Guidance literature:

With copper immobilized at polyimide covalent organic framework; In methanol; water; at 20 ℃; for 8h;

DOI:10.1039/c8gc02611d

upstream raw materials:

N-(1-Phenyl-1H-indazol-3-yl)-benzamide

o-cyanobromobenzene

N-benzoyl-N'-phenylhydrazine

3-aminoindazole

Refernces

• 1、 Zhu, W. Felix,Kr?mer, Andreas,Knapp, Stefan,Proschak, Ewgenij,Hernandez-Olmos, Victor. "Cascade Synthesis of Kinase-Privileged 3-Aminoindazoles via Intramolecular N-N Bond Formation". . p. 3856 - 3862. Retrieved 2022/03/02.
• 2、 -. "Method for preparing substituted 3-aminoindazole compound in one step". Paragraph 0023-0111. . Retrieved 2020/07/28.