2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate

Base Information

• Chemical Name: 2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate
• CAS No.: 948837-82-9
• Molecular Formula: C₁₃H₁₅NO₂S₃
• Molecular Weight: 313.466
• Mol file: 948837-82-9.mol

Synonyms:2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate

Chemical Property of 2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate

There total 2 articles about 2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

3-Acetamidoacetophenone (7463-31-2) + sodium ethyltrithiocarbonate (67715-76-8) → 2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate (948837-82-9)

Guidance literature:

3-Acetamidoacetophenone; With N,N,N-trimethylanilinium bromide; In tetrahydrofuran; at 20 ℃;

sodium ethyltrithiocarbonate; In tetrahydrofuran;

DOI:10.1021/jm800093c

Reference yield:

carbon disulfide (75-15-0,12122-00-8) + 1-(3-Acetylaminophenyl)-2-bromoethanone (30095-56-8) + sodium thioethylate (811-51-8) → 2-(3-acetylaminophenyl)-2-oxoethyl ethyl trithiocarbonate (948837-82-9)

Guidance literature:

carbon disulfide; sodium thioethylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

1-(3-Acetylaminophenyl)-2-bromoethanone; In tetrahydrofuran; at 20 ℃; Further stages.;

DOI:10.1016/j.bmcl.2007.06.063

upstream raw materials:

carbon disulfide

1-(3-Acetylaminophenyl)-2-bromoethanone

sodium thioethylate

3-Acetamidoacetophenone

Refernces

• 1、 Dehmel, Florian,Ciossek, Thomas,Maier, Thomas,Weinbrenner, Steffen,Schmidt, Beate,Zoche, Martin,Beckers, Thomas. "Trithiocarbonates-Exploration of a new head group for HDAC inhibitors". . p. 4746 - 4752. Retrieved 2008/12/21.