Phenol, 2-fluoro-3-nitro- (9CI)

Base Information

• Chemical Name: Phenol, 2-fluoro-3-nitro- (9CI)
• CAS No.: 179816-26-3
• Molecular Formula: C₆H₄FNO₃
• Molecular Weight: 157.101
• Hs Code.: 2908999090
• Mol file: 179816-26-3.mol

Synonyms:Phenol, 2-fluoro-3-nitro- (9CI);2-Fluoro-3-nitrophenol, 95+%

Chemical Property of Phenol, 2-fluoro-3-nitro- (9CI)

Chemical Property:

• Vapor Pressure: 0.00523mmHg at 25°C
• Refractive Index: 1.581
• Boiling Point: 266.5 °C at 760 mmHg
• PKA: 8.12±0.25(Predicted)
• Flash Point: 115 °C
• PSA: 66.05000
• Density: 1.511 g/cm³
• LogP: 1.96270
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-fluoro-3-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phenol, 2-fluoro-3-nitro- (9CI)

There total 1 articles about Phenol, 2-fluoro-3-nitro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3-hydroxy-2-fluoronitrobenzene (179816-26-3)

Guidance literature:

Reference yield:

3-hydroxy-2-fluoronitrobenzene (179816-26-3) + (2,6-dimethylphenyl)((3S)-3-hydroxypyrrolidin-1-yl)methanone → (2,6-dimethylphenyl)((3S)-3-(2-fluoro-3-nitrophenoxy)pyrrolidin-1-yl)methanone

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 50 ℃; for 20h;

Reference yield:

3-hydroxy-2-fluoronitrobenzene (179816-26-3) + trifluoromethylsulfonic anhydride (358-23-6) → C7H3F4NO5S

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.jmedchem.0c01116

Refernces