5-Fluoro-2-indanone

Base Information

• Chemical Name: 5-Fluoro-2-indanone
• CAS No.: 57584-69-7
• Molecular Formula: C₉H₇FO
• Molecular Weight: 150.152
• Mol file: 57584-69-7.mol

Synonyms:5-Fluoro-2-indanone;

Chemical Property of 5-Fluoro-2-indanone

Chemical Property:

• Boiling Point: 242.651 ºC at 760 mmHg
• Flash Point: 86.148 ºC
• Density: 1.259

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-1H-inden-2(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-2-indanone

There total 4 articles about 5-Fluoro-2-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-fluoro-4-(prop-2-yn-1-yl)benzene (70090-68-5) → 5-fluoro-1H-inden-2(3H)-one (57584-69-7)

Guidance literature:

With 2-(tert-butyl)-6-chloropyridine 1-oxide; C₄₅H₅₇AuF₆NO₉PS₂; In chloroform; at 60 ℃; for 6h;

DOI:10.1002/anie.201301015

Reference yield:

4-fluorophenylacetonitrile (459-22-3) → 5-fluoro-1H-inden-2(3H)-one (57584-69-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane; cyclohexane / 0.25 h / 0 °C

2.1: triphenylphosphine / dichloromethane / 0.5 h / 0 °C

2.2: 3 h / 0 °C

3.1: tert.-butyl lithium / tetrahydrofuran / -78 - 20 °C

4.1: 2-(tert-butyl)-6-chloropyridine 1-oxide; C₄₅H₅₇AuF₆NO₉PS₂ / chloroform / 6 h / 60 °C

With 2-(tert-butyl)-6-chloropyridine 1-oxide; C₄₅H₅₇AuF₆NO₉PS₂; tert.-butyl lithium; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; chloroform; cyclohexane;

DOI:10.1002/anie.201301015

Reference yield:

4-fluorophenylacetaldehyde (1736-67-0) → 5-fluoro-1H-inden-2(3H)-one (57584-69-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triphenylphosphine / dichloromethane / 0.5 h / 0 °C

1.2: 3 h / 0 °C

2.1: tert.-butyl lithium / tetrahydrofuran / -78 - 20 °C

3.1: 2-(tert-butyl)-6-chloropyridine 1-oxide; C₄₅H₅₇AuF₆NO₉PS₂ / chloroform / 6 h / 60 °C

With 2-(tert-butyl)-6-chloropyridine 1-oxide; C₄₅H₅₇AuF₆NO₉PS₂; tert.-butyl lithium; triphenylphosphine; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1002/anie.201301015

upstream raw materials:

1-fluoro-4-(prop-2-yn-1-yl)benzene

4-fluorophenylacetonitrile

4-fluorophenylacetaldehyde

Downstream raw materials:

2,2,5-Trifluorindan

Refernces