Tetrahydrothiopyran-4-carbaldehyde

Base Information

• Chemical Name: Tetrahydrothiopyran-4-carbaldehyde
• CAS No.: 50675-19-9
• Molecular Formula: C6H10OS
• Molecular Weight: 130.211
• Hs Code.: 2934999090
• Mol file: 50675-19-9.mol

Synonyms:Tetrahydro-2H-thiopyran-4-carboxaldehyde;Tetrahydrothiopyran-4-carboxaldehyde;

Chemical Property of Tetrahydrothiopyran-4-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.136mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 217 °C at 760 mmHg
• Flash Point: 97.2 °C
• PSA: 42.37000
• Density: 1.157 g/cm³
• LogP: 1.32850

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydrothiopyran-4-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydrothiopyran-4-carbaldehyde

There total 7 articles about Tetrahydrothiopyran-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(methoxymethylene)-3,4,5,6-tetrahydro-2H-thiopyran (131992-30-8) → 4-thianylcarbaldehyde (50675-19-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; at 5 - 20 ℃; for 4h;

Reference yield: 56.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-methoxy-3-methyl-4-oxa-8-thia-1,2-diazaspiro[4.5]dec-1-ene → 4-thianylcarbaldehyde (50675-19-9)

Guidance literature:

In 2-methyltetrahydrofuran; water; at 20 ℃; Inert atmosphere; UV-irradiation;

DOI:10.1021/acs.joc.8b02721

Reference yield:

(tetrahydro-2H-thiopyran-4-yl)methanol (100277-27-8) → 4-thianylcarbaldehyde (50675-19-9)

Guidance literature:

(tetrahydro-2H-thiopyran-4-yl)methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -45 - -30 ℃; for 1.08333h;

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

upstream raw materials:

(tetrahydro-2H-thiopyran-4-yl)methanol

oxalyl dichloride

Tetrahydrothiopyran-4-one

4-(methoxymethylene)-3,4,5,6-tetrahydro-2H-thiopyran

Downstream raw materials:

C₁₄H₂₁NO₂S

4-ethynyltetrahydro-2H-thiopyran

1,1-dioxo-hexahydro-1λ⁶-thiopyran-4-carbaldehyde

2-((R)-(1-(1,1-dioxohexahydro-1λ6-thiopyran-4-yl)methylamino)ethyl)-3-(4-chlorophenyl)pyrido[2,3d]pyrimidin-4(3H)-one

Refernces

• 1、 -. "Azacyclo diketone compound and preparation method thereof". . . Retrieved 2020/06/17.
• 2、 Iosub, Andrei V.,Morav?ík, ?tefan,Wallentin, Carl-Johan,Bergman, Joakim. "Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes". supporting information. p. 7804 - 7808. Retrieved 2019/10/14.