6-Methoxy-2-trifluoromethyl-3-nitropyridine

Base Information

• Chemical Name: 6-Methoxy-2-trifluoromethyl-3-nitropyridine
• CAS No.: 727993-33-1
• Molecular Formula: C₇H₅F₃N₂O₃
• Molecular Weight: 222.124
• Mol file: 727993-33-1.mol

Synonyms:6-Methoxy-2-trifluoromethyl-3-nitropyridine;6-Methoxy-3-nitro-2-(trifluoromethyl)pyridine

Chemical Property of 6-Methoxy-2-trifluoromethyl-3-nitropyridine

Chemical Property:

• Vapor Pressure: 0.0248mmHg at 25°C
• Boiling Point: 256.4°C at 760 mmHg
• Flash Point: 108.8°C
• PSA: 67.94000
• Density: 1.461g/cm³
• LogP: 2.54040
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxy-3-nitro-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Methoxy-3-nitro-2-(trifluoromethyl)pyridine is used in the synthasis of pyrazinones as corticotropin-releasing factor -1 (CFR1) receptor antagonists.

Technology Process of 6-Methoxy-2-trifluoromethyl-3-nitropyridine

There total 2 articles about 6-Methoxy-2-trifluoromethyl-3-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-chloro-6-methoxy-3-nitropyridine (38533-61-8) + metyhyl chlorodifluoroacetate (1514-87-0) → 6-methoxy-3-nitro-2-(trifluoromethyl)pyridine (727993-33-1)

Guidance literature:

2-chloro-6-methoxy-3-nitropyridine; metyhyl chlorodifluoroacetate; With potassium fluoride; copper(l) iodide; In N,N-dimethyl-formamide; at 125 ℃; for 13h;

With ammonia; ammonium chloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield: 53.0%

2-chloro-6-methoxy-3-nitropyridine (38533-61-8) + dibromodifluoromethane (75-61-6) → 6-methoxy-3-nitro-2-(trifluoromethyl)pyridine (727993-33-1)

Guidance literature:

With copper; In ISOPROPYLAMIDE; at 20 - 100 ℃; for 8h;

Reference yield: 71.0%

6-methoxy-3-nitro-2-(trifluoromethyl)pyridine (727993-33-1) → 6-methoxy-2-(trifluoromethyl)pyridin-3-amine (727993-34-2)

Guidance literature:

With tin(ll) chloride; In ethanol; at 70 ℃; for 3h;

upstream raw materials:

2-chloro-6-methoxy-3-nitropyridine

metyhyl chlorodifluoroacetate

dibromodifluoromethane

Downstream raw materials:

6-methoxy-2-(trifluoromethyl)pyridin-3-amine

3-iodo-6-methoxy-2-(trifluoromethyl)pyridine

2'-benzyloxy-6-methoxy-3'-nitro-2-trifluoromethyl-[3,4']bipyridinyl

Refernces

• 1、 -. "THERAPEUTICALLY ACTIVE THIAZOLO-PYRIMIDINE DERIVATIVES". Page/Page column 57. . Retrieved 2013/05/23.
• 2、 -. "Heterocyclic FXR binding compounds". Page/Page column 26. . Retrieved 2008/06/13.