4-(Bromomethyl)-2,6-di-tert-butylpyridine

Base Information

• Chemical Name: 4-(Bromomethyl)-2,6-di-tert-butylpyridine
• CAS No.: 81142-32-7
• Molecular Formula: C14H22BrN
• Molecular Weight: 284.23
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30513259
• Nikkaji Number: J2.188.094I
• Wikidata: Q72447076
• Mol file: 81142-32-7.mol

Synonyms:4-(Bromomethyl)-2,6-di-tert-butylpyridine;81142-32-7;4-(bromomethyl)-2,6-ditert-butylpyridine;4-(Bromomethyl)-2,6-di(tert-butyl)pyridine;C14H22BrN;SCHEMBL6674053;YSCK0231;DTXSID30513259;KRGQGAXLBUQGQP-UHFFFAOYSA-N;4-bromomethyl-2,6-di-t-butylpyridine;AKOS015891772;4-bromomethyl-2,6-di-tert-butylpyridine;BS-17599;FT-0654172;D84213;A840052

Chemical Property of 4-(Bromomethyl)-2,6-di-tert-butylpyridine

Chemical Property:

• Vapor Pressure: 0.00595mmHg at 25°C
• Refractive Index: 1.512
• Boiling Point: 281.8 °C at 760 mmHg
• Flash Point: 124.2 °C
• PSA: 12.89000
• Density: 1.157 g/cm³
• LogP: 4.57150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 283.09356
• Heavy Atom Count: 16
• Complexity: 202

Purity/Quality:

98%min ^*data from raw suppliers

4-(Bromomethyl)-2,6-di-tert-butylpyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)C1=CC(=CC(=N1)C(C)(C)C)CBr

Technology Process of 4-(Bromomethyl)-2,6-di-tert-butylpyridine

There total 1 articles about 4-(Bromomethyl)-2,6-di-tert-butylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-di-tert-butyl-4-methylpyridine (38222-83-2) → (2,6-di-tert-butyl-4-pyridyl)methylene bromide (81142-32-7)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 5h; Heating;

DOI:10.1080/104265091001056

Reference yield: 77.0%

5-(hydroxymethyl)benzene-1,3-diol (29654-55-5) + (2,6-di-tert-butyl-4-pyridyl)methylene bromide (81142-32-7) → 3,5-bis(2,6-di-tert-butylpyridin-4-ylmethoxy)benzyl alcohol (862009-38-9)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 72h; Heating;

DOI:10.1055/s-2005-865355

Reference yield:

(2,6-di-tert-butyl-4-pyridyl)methylene bromide (81142-32-7) + benzoic acid (65-85-0,8013-63-6) → (2,6-di-tert-butylpyridin-4-yl)methyl benzoate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;

upstream raw materials:

2,6-di-tert-butyl-4-methylpyridine

Downstream raw materials:

3,5-bis(2,6-di-tert-butylpyridin-4-ylmethoxy)benzyl alcohol

3,5-bis(2,6-di-tert-butylpyridin-4-ylmethoxy)benzyl bromide

3,5-bis[3,5-bis(2,6-di-tert-butylpyridin-4-ylmethoxy)benzyloxy]benzyl alcohol

Refernces

• 1、 Hashimoto, Yuichi,Ohgane, Kenji,Sagimori, Ikuya,Toyota, Yosuke,Yoshioka, Hiromasa. "Bisphosphonate esters interact with HMG-CoA reductase membrane domain to induce its degradation". . . Retrieved 2020/06/18.
• 2、 Suarez, Diana,Laval, Gilles,Tu, Shang-Min,Jiang, Dong,Robinson, Claire L.,Scott, Richard,Golding, Bernard T.. "Benzylic brominations with N-bromosuccinimide in (Trifluoromethyl)benzene". experimental part. p. 1807 - 1810. Retrieved 2010/02/28.