2-Amino-6-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 2-Amino-6-(trifluoromethyl)pyridine
• CAS No.: 34486-24-3
• Molecular Formula: C6H5F3N2
• Molecular Weight: 162.114
• Hs Code.: 29333990
• European Community (EC) Number: 636-458-9
• DSSTox Substance ID: DTXSID00356271
• Nikkaji Number: J2.152.094B
• Wikidata: Q72442848
• Mol file: 34486-24-3.mol

Synonyms:2-Amino-6-(trifluoromethyl)pyridine;34486-24-3;6-(trifluoromethyl)pyridin-2-amine;6-(trifluoromethyl)-2-pyridinylamine;MFCD03093868;2-Pyridinamine, 6-(trifluoromethyl)-;6-(trifluoromethyl)-2-pyridinamine;2-amino-6-trifluoromethylpyridine;SCHEMBL181081;6-trifluoromethylpyridin-2-amine;DTXSID00356271;PBPDHPGJRZUHJW-UHFFFAOYSA-N;6-trifluoromethyl-pyridin-2ylamine;2-amino-6-trifluoromethyl-pyridine;BBL102644;STL556447;AKOS005063709;AB13269;AC-2642;CS-W002995;DS-1625;FS-1212;SY002370;2-Amino-6-(trifluoromethyl)pyridine, 97%;AM20051097;FT-0602604;EN300-61496;Q-101477;W-201125;Z858035348

Chemical Property of 2-Amino-6-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.123mmHg at 25°C
• Melting Point: 85-89 °C
• Refractive Index: 1.447
• Boiling Point: 192.1 °C at 760 mmHg
• PKA: 3.13±0.24(Predicted)
• Flash Point: 70 °C
• PSA: 38.91000
• Density: 1.368 g/cm³
• LogP: 2.26380
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Hygroscopic
• Solubility.: soluble in Methanol
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 162.04048265
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-6-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T,Xi,Xn
• Statements: 25-36/37/38-43-20/21/22
• Safety Statements: 26-36/37-45-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)N)C(F)(F)F
• Uses: Substrate used in a one-pot synthesis of the corresponding 7-aza-indole.

Technology Process of 2-Amino-6-(trifluoromethyl)pyridine

There total 3 articles about 2-Amino-6-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-fluoro-6-(trifluoromethyl)pyridine (94239-04-0) → 2-amino-6-(trifluoromethyl)pyridine (34486-24-3)

Guidance literature:

With acetamidine hydrochloride; sodium hydroxide; In water; dimethyl sulfoxide; at 130 ℃; for 24h; chemoselective reaction; Schlenk technique;

DOI:10.1039/c8ob02129e

Reference yield: 82.0%

→ 2-amino-6-(trifluoromethyl)pyridine (34486-24-3)

Guidance literature:

With acetamidine hydrochloride; sodium hydroxide; In water; dimethyl sulfoxide; at 130 ℃; for 24h;

Reference yield:

2-chloro-6-trifluoromethylpyridine (39890-95-4) → 2-amino-6-(trifluoromethyl)pyridine (34486-24-3)

Guidance literature:

With ammonium hydroxide; at 180 ℃;

DOI:10.1021/jm9705059

upstream raw materials:

2-chloro-6-trifluoromethylpyridine

2-fluoro-6-(trifluoromethyl)pyridine

Downstream raw materials:

(C₅H₃(6-CF₃)N)(2-NH(B(C₆F₅)2)

C₁₇H₁₀F₄N₄O₂

C₁₇H₁₀ClF₃N₄O₂

2-chloro-6-trifluoromethylpyridine

Refernces

• 1、 Li, Yibiao,Huang, Shuo,Liao, Chunshu,Shao, Yan,Chen, Lu. "Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride". supporting information. p. 7564 - 7567. Retrieved 2018/11/02.
• 2、 -. "Amino naphthyridine compounds as anti-rhoumatic agents". . . Retrieved 2008/06/13.