2-Chloro-4-methoxy-5-nitropyridine

Base Information

• Chemical Name: 2-Chloro-4-methoxy-5-nitropyridine
• CAS No.: 607373-83-1
• Molecular Formula: C6H5ClN2O3
• Molecular Weight: 188.57
• Hs Code.: 2933399090
• Mol file: 607373-83-1.mol

Synonyms:2-Chloro-4-methoxy-5-nitropyridine;2-Chloro-4-Methoxy-5-Nitro Pyridine;

Chemical Property of 2-Chloro-4-methoxy-5-nitropyridine

Chemical Property:

• Vapor Pressure: 0.00102mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 311.6 °C at 760 mmHg
• PKA: -2.11±0.10(Predicted)
• Flash Point: 142.3 °C
• PSA: 67.94000
• Density: 1.445g/cm³
• LogP: 2.17500
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-4-methoxy-5-nitropyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-methoxy-5-nitropyridine

There total 3 articles about 2-Chloro-4-methoxy-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-4-methoxy-5-nitro pyridine (607373-82-0) → 2-chloro-4-methoxy-5-nitro-pyridine (607373-83-1)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-aniline; at 10 ℃; for 2h; Solvent; Temperature; Reflux;

Reference yield:

4-methoxy-3-nitro-pyridine (31872-62-5) → 2-chloro-4-methoxy-5-nitro-pyridine (607373-83-1)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia; potassium tert-butylate; tert.-butylhydroperoxide / tetrahydrofuran / 1 h / -30 - -25 °C

2: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 10 °C / Reflux

With tert.-butylhydroperoxide; potassium tert-butylate; ammonia; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-aniline;

Reference yield:

→ 2-chloro-4-methoxy-5-nitro-pyridine (607373-83-1)

Guidance literature:

With potassium carbonate; In acetone; at 40 ℃;

upstream raw materials:

2-hydroxy-4-methoxy-5-nitro pyridine

4-methoxy-3-nitro-pyridine

Downstream raw materials:

cyano(4-methoxy-5-nitro-pyridin-2-yl)acetic acid tert-butyl ester

6-(4-methyl-piperazin-1-yl)-4-o-tolylpyridin-3-yl-amine

methyl-[6-(4-methyl-piperazin-1-yl)-4-o-tolyl-pyridin-3-yl]-amine

netupitant

Refernces

• 1、 -. "TRIAZOLONE COMPOUNDS AND USES THEREOF". Paragraph 00219; 00283. . Retrieved 2013/09/26.