TETRAHYDRO-FURAN-3-YLAMINE HCL

Base Information

• Chemical Name: TETRAHYDRO-FURAN-3-YLAMINE HCL
• CAS No.: 204512-94-7
• Molecular Formula: C₄H₉NO*ClH
• Molecular Weight: 123.582
• Hs Code.: 2932190090
• Mol file: 204512-94-7.mol

Synonyms:3-Furanamine,tetrahydro-, hydrochloride (9CI);3-Aminotetrahydrofuran hydrochloride;Tetrahydrofuran-3-amine hydrochloride;

Chemical Property of TETRAHYDRO-FURAN-3-YLAMINE HCL

Chemical Property:

• Boiling Point: 173.5 °C at 760 mmHg
• Flash Point: 58.7 °C
• PSA: 35.25000
• LogP: 1.23630
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-AminotetrahydrofuranHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Aminotetrahydrofuran Hydrochloride is an intermediate used to prepare N-6 heterocyclic substituted nucleosides as adenosine receptors.

Technology Process of TETRAHYDRO-FURAN-3-YLAMINE HCL

There total 5 articles about TETRAHYDRO-FURAN-3-YLAMINE HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(S)-3-benzoylamino-tetrahydrofuran (152495-79-9,872303-09-8) → (3S)-tetrahydrofuran-3-amine hydrochloride (204512-95-8,1185756-83-5,204512-94-7)

Guidance literature:

(S)-3-benzoylamino-tetrahydrofuran; With water; sodium hydroxide; In ethanol; for 10h; Reflux;

With hydrogenchloride; In ethanol; water;

DOI:10.1016/j.tetasy.2013.04.007

Reference yield:

C11H15NO3S (1070789-73-9) → (3S)-tetrahydrofuran-3-amine hydrochloride (204512-95-8,1185756-83-5,204512-94-7)

Guidance literature:

C₁₁H₁₅NO₃S; With methanol; magnesium;

With hydrogenchloride; Product distribution / selectivity;

Reference yield:

C14H15NO3S → (3S)-tetrahydrofuran-3-amine hydrochloride (204512-95-8,1185756-83-5,204512-94-7)

Guidance literature:

C₁₄H₁₅NO₃S; With methanol; magnesium;

With hydrogenchloride; Product distribution / selectivity;

upstream raw materials:

(tetrahydrofuran-3-yl)carbamic acid tert-butyl ester

(S)-3-benzoylamino-tetrahydrofuran

C₁₁H₁₅NO₃S

Downstream raw materials:

C₃₂H₃₂F₂N₄O₆

(S)-4-bromo-2-fluoro-6-((tetrahydrofuran-3-yl)amino)benzonitrile

(S)-2-fluoro-5-(N-(tetrahydrofuran-3-yl)sulfamoyl)benzoic acid

Refernces

• 1、 -. "Processes for the Manufacture of Chiral and Racemic Forms of 3-Aminotetrahydrofurans, Their Salts and Derivatives". Page/Page column 3. . Retrieved 2008/12/04.
• 2、 -. "N6 mono heterocyclic substituted adenosine derivatives". . . Retrieved 2008/06/13.